BACKGROUND The small sample volume needed and the prompt availability of results make viscoelastic methods like rotational thromboelastometry (ROTEM) attractive for monitoring coagulation in small children. However, data on reference ranges for ROTEM parameters in children are scarce. METHODS Four hundred and seven children (ASA I and II) undergoing elective surgery were recruited for this pr...

BACKGROUND Plasma-free volume replacement in haemorrhage often results in dilutional coagulopathy. Prothrombin time index (PTI) and activated partial thromboplastin time (aPTT) are used for monitoring haemostasis but have not yet been clinically evaluated. Our aim was to investigate the effects of haemodilution on the course of global coagulation tests and clotting factors (CFs). METHODS Bloo...

Dicofol is an organochlorine miticide utilized for killing Red spite, vermin and so on generally utilised in cultivating and development fields like agriculture items. It is in an indistinguishable synthetic class from DDT and has a practically indistinguishable structure, varying by only one additional oxygen atom. Its harmfulness, solid impact, and malignancy causing nature influenced the con...

The efficacy of oral aspirin treatment in the secondary prevention of cardio and cerebro vascular disease is well known. However oral administration is often associated with abdominal discomfort. The feasibility of delivering aspirin transdermally from eudragit and polyvinyl acetate (PVA) matrix-type patches to enhance its antithrombotic efficiency of aspirin was investigated. Transdermal films...

OBJECTIVE Acromegaly is associated with increased cardiovascular morbidity and mortality. The data about the evaluation of coagulation and fibrinolysis in acromegalic patients are very limited and to our knowledge, platelet function analysis has never been investigated. So, we aimed to investigate the levels of protein C, protein S, fibrinogen, antithrombin 3 and platelet function analysis in p...

Pierre Toulon1; Micheline Berruyer2; Marie Brionne-François3; François Grand4; Dominique Lasne5; Caroline Telion6; Julien Arcizet2; Roberta Giacomello7; Neila De Pooter8 1Université Nice Sofia-Antipolis, CHU Pasteur, Service d’Hématologie Biologique, Nice, France; 2Laboratoire d’Hématologie, GH Est, Bron, France; 3Laboratoire d’Hématologie, CHU Côte de Nacre, Caen, France; 4Laboratoire d’Hémato...

BACKGROUND Use of age-adjusted reference values is crucial for correct diagnosis and management of thrombotic and hemorrhagic disease in children. They vary with utilized reagents and analyzers. OBJECTIVES We established reference values with the Sysmex CA-1500 System and in parallel with the Behring BCS System using reagents from Siemens Healthcare Diagnostics Products GmbH. METHODS After ...

The severity of liver disease is assessed by scoring systems, which include the conventional coagulation test prothrombin time-the international normalized ratio (PT-INR). However, PT-INR is not predictive of bleeding in liver disease and thromboelastometry (ROTEM) has been suggested to give a better overview of the coagulation system in these patients. It has now been suggested that coagulatio...

The present study reported the case of a Chinese boy who was diagnosed with Moyamoya disease (MMD) associated with Graves' disease (GD). An overactivation of von Willebrand factor (vWF) and coagulation factor VIII (FVIII) was identified in the plasma of the patient. Thiamazole and metoprolol treatment was thus administrated. After 2 months of treatment, the patient's thyroid function returned t...