Cobalamin is essential for growth of Euglena gracilis and photosynthesis. Methylcobalamin in Euglena chloroplasts (Y Isegawa, Y Nakano, S Kitaoka, 1984 Plant Physiol 76: 814-818) functions as a coenzyme of methionine synthetase. The requirement of cobalamin for photosynthesis appeared remarkably high in Euglena grown under the dark-precultured condition. The required amount of cobalamin for nor...

BACKGROUND Delirium is common after cardiac surgery and is independently associated with increased morbidity, mortality, prolonged hospital stays, and higher costs. Cobalamin (vitamin B12) deficiency is a common cause of neuropsychiatric symptoms and affects up to 40% of elderly people. The relationship between cobalamin deficiency and the occurrence of delirium after cardiac surgery has not be...

Elevated propionyl C3 carnitine is the most common abnormality seen in tandem mass spectrometry newborn screening profiles, with an incidence of 0.15% seen in our South Australian newborn screening programme. The most common cause for this result in our population is vitamin B12 deficiency but differential diagnoses include the inherited disorders of propionic and methylmalonic acid metabolism ...

Vitamins are essential for a healthy life. Compared to other nutrients, the body needs them in very small amounts. B vitamins, often known as vitamin complex, class of water-soluble vitamins with key functions cellular metabolism. Thiamine (vitamin B1), riboflavin B2), niacin B3), pantothenic acid B5), pyridoxine B6), biotin B7), folate B9), folic acid, and cobalamin B12) eight distinct that co...

But very frequently among those patients, careful inquiries demonstrate that no external human intervention may explain the finding. So we have to find some explanation to the increase within the metabolism. The presence of vitamin B12 in human faeces doesn’t only correspond to what is left from the absorption in the ileum, but it also reflects the production of significant quantities of cobala...

Cff%E OF PROJECT: Research in Marine Fungi Objectives: (l) Development of a metal-buffer6d artificial sea water and a more defined medium to peinlt harvesting large quantities of Labyrlnthula cells. (2) Development of a completely synthetic medium for Thraustochytrium and determination of its response to cobalamin. (3) Determination of the specificity of the steroid requirement of Labyrlnthula ...

BACKGROUND In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency. OBJECTIVE The objective was to examine indicators of cobalamin status in Asian Indians. DESIGN The study population included 204 men and women aged 27-55 y from Pune, Maharashtra, India, categorized into 4 groups: patients with cardiovascular disease (CVD) and diabetes, patients with CVD bu...

Treatment with the anti-diabetic drug metformin is followed by a decline in plasma cobalamin, but it is unsettled whether this denotes an impaired cobalamin status. This study has explored changes in the markers of cobalamin status in women with Polycystic Ovary Syndrome treated with metformin (1.5-2.5 g per day) (n = 29) or placebo (n = 23) for six months. Serum samples were collected before a...

Pancreatic proteases degrade the protein moiety of the R protein-cobalamin complex but not the intrinsic factor-cobalamin complex. Accordingly, we used these two proteins as substrates in an in vitro enzymatic assay to assess pancreatic function by incubating basal jejunal fluids with a mixture of intrinsic factor and cyano[57Co]cobalamin coupled to R-type protein and then using immunoprecipita...

Diagnosing cobalamin deficiency is often difficult. We investigated the diagnostic strategies that 224 general practitioners used to assess cobalamin status and the criteria on which they based their decisions to supplement patients. From all serum cobalamin analyses carried out at a single laboratory during 1993, individuals with serum cobalamin concentrations <300 pmol/L were identified, and ...