De novo syntheses of amides often generate stoichiometric amounts of waste. Thus, recent progress in the field has focused on precious metal catalyzed, oxidative protocols to generate such functionalities. However, simple tertiary alkyl amines cannot be used as starting materials in these protocols. The research described herein enables the oxidative synthesis of amides from simple, noncyclic t...

Soot concentration measurements in ethylene-O2/CO2 diffusion flames (fuel Re 120) encompassing oxidizer oxygen mole fractions (oxygen index, OI) of 35% to 90% were employed validate a methodology for modeling soot production. A skeletal 10-step reaction mechanism and the nucleation parameter (Cα) Moss-Brookes model as function OI provided adequate agreement with measurements. Cross-validation b...

Characterization of acidic peptides and proteins is greatly hindered due to lack of suitable analytical techniques. Here we present the implementation of 213 nm ultraviolet photodissociation (UVPD) in high-resolution quadrupole-Orbitrap mass spectrometer in negative polarity for peptide anions. Radical-driven backbone fragmentation provides 22 distinctive fragment ion types, achieving the compl...

The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at Cα, such amide bond surrogates need a chiral moiety. Here the asymmetric synthesis of a set of 24...

Interactions between α-helices within the hydrophobic environment of lipid bilayers are integral to the folding and function of transmembrane proteins; however, the major forces that mediate these interactions remain debated, and our ability to predict these interactions is still largely untested. We recently demonstrated that the frequent transmembrane association motif GASright, the GxxxG-con...

Lemma 1. For any > 0 and κ ∈ [, 1], we have V(κ) − V(κ −) ≤ Cα log 2 (1//). Proof. By monotonicity, it suffices to prove that result for κ = 1. Notice that for K ≥ 2α,

geotechnical investigations of waste fills are rarely undertaken, and consequently the geotechnical community has little knowledge of their engineering properties. in this study, a geotechnical testing program was conducted to evaluate the engineering properties of old municipal solid waste sampled in whamyung msw landfill site, busan, korea. the conducted tests included water content, specific...

Metallacyclobutanes are an important class of organometallic intermediates, due to their role in olefin metathesis. They can have either planar or puckered rings associated with characteristic chemical and physical properties. Metathesis active metallacyclobutanes have short M-Cα/α' and M···Cβ distances, long Cα/α'-Cβ bond length, and isotropic 13C chemical shifts for both early d0 and late d4 ...

In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates is packing density. The packing density measure that best correlates with rates is the weighted contact number (WCN), the sum of inverse square distances between the site’s Cα and the other Cα . According to a mechan...

In this paper we use Groebner bases theory with the purpose to determine planarity of intersections of two algebraic surfaces in R. There are specially considered plane sections of a type of conoid which has a cubic egg curve as one of the directrices. The paper investigates a possibility of conic plane sections of this type of conoid. 1. THE BASIC CONCEPT OF GROEBNER BASES Many problems in mat...