Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are currently the most effective medications for reducing low-density lipoprotein cholesterol concentrations. Although generally safe, they have been associated with a variety of myopathic complaints. Statins block production of farnesyl pyrophosphate, an intermediate in the synthesis of ubiquinone or coenzyme Q10 (CoQ10). Thi...

Nephropathy is one of the most severe complications of diabetic patients. The therapeutic strategies for diabetic patients should not only focus on the control of blood glucose but also pay attention to the occurrence of diabetic nephropathy (DN). Coenzyme Q10 (CoQ10) has great therapeutic potential for DN. However, the clinical application of CoQ10 has been limited because of its low water-sol...

PURPOSE Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of infertility, general, owing its antioxidant properties. Thus, present study intends investigate effects CoQ10 therapy on semen parameters, oxidative markers SDF infertile men, specifically with ...

Although coenzyme Q10 (CoQ10) serves as an antioxidant and energy source for spermatozoa when added to stallion semen before cooling or freezing, the effects of feeding CoQ10 on quality have not been studied. We assessed daily oral ingestion CoQ10-ubiquinol by stallions their plasma concentrations quality. Seven mature Andalusian ate 1g ubiquinol/day 4 weeks followed a 4-week washout period. Fo...

Background: Polycystic ovary syndrome (PCOS) is the largest single cause of anovulatory infertility. PCOS associated with oxidative stress. Coenzyme q10 (Coq10) an antioxidant that protects mitochondria from damage caused by either insulin resistance or free radicals. The objective study was to compare effect combined Coq10 and letrozole than alone for ovulation induction in women PCOS.Methods:...

Coenzyme Q10 (CoQ10) acts as an antioxidant that protects the cells by preventing lipid peroxidation. Owing to its low solubility, CoQ10 has shown poor delivery properties and bioavailability. The aim of this study is develop loaded cubosomes in order enhance oral hepatoprotective activity. Cubosomes are cubic nanostructured systems resulting from colloidal dispersion liquid crystalline structu...

BACKGROUND & AIMS Chronic Fatigue Syndrome (CFS) is a complex condition, characterized by severe disabling fatigue with no known cause, no established diagnostic tests, and no universally effective treatment. Several studies have proposed symptomatic treatment with coenzyme Q10 (CoQ10) and nicotinamide adenine dinucleotide (NADH) supplementation. The primary endpoint was to assess the effect of...

Background: Fatigue is a common side effect in cancer patients undergoing radiation therapy (RT). Radiation-induced fatigue affects the quality of life, but there is no definitive treatment option. In this study, the weight-loaded forced swim test was performed to assess the effect of coenzyme Q10 (CoQ10) on radiation-induced fatigue. Materials and Methods: A total of 60 rats were divided rando...

Coenzyme Q10 (CoQ10) is synthesized in almost all human tissues and presumably involved in age-related alterations and diseases. Here, we examined the impact of aging and sex on the serum CoQ10 status in 860 European adults ranging in age from 18 to 82 years. We identified an inverse U-shaped relationship between CoQ10 concentration and age. Women showed lower cholesterol-adjusted CoQ10 levels ...

Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid. Mutations in enzymes that participate to coenzyme Q biosynthesis result in primary coenzyme Q deficiency, a type of mitochondrial disease. Coenzyme Q10 supplementation of patients is the classical treatment but it shows limited effic...