Bre1, a conserved E3 ubiquitin ligase in Saccharomyces cerevisiae, together with its interacting partner Lge1, are responsible for histone H2B monoubiquitination, which regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. Deletion of BRE1 or LGE1 also results in whole chromosome instability. We discovered a novel role for...

Article 2 of the Treaty on European Union (TEU) makes it clear that cohesion is one of the fundamental principles the EU seeks to respect. Cohesion, however, is not an easy concept to pin down, although it is linked (in Article 130A of the TEU) to disparities between regions. In practice, what constitutes cohesion is a political rather than an economic judgment; disparities tolerable today may ...

Cohesion increased for several months after disruption in moist soils. Rate at which cohesion increased was slower in airdry soil, but continued for years. Moduli of rupture of soils also increased with time. Effects of water content on the rate at which cohesion increases are compatible with an explanation of the bonding mechanism in terms of slightly soluble components diffusing to and cement...

In order to improve the quality of an application during the development process, developers use several metrics. These metrics measure the different software attributes such as cohesion, coupling and complexity. To measure the class cohesion several class cohesion metrics have been introduced till date. Cohesion is measured during the design phase to predict software quality. A high cohesive m...

The purpose of this study was to investigate Paralympic coaches' perceptions of team cohesion. Seven head coaches of summer and winter Canadian Paralympic sport teams participated in the study. Four participants coached individual sports and 3 coached team sports. Data were collected using semistructured interviews and analyzed using thematic analysis. The results addressed the coaches' percept...

Two measures of lexical cohesion were developed and applied to a corpus of human-computer tutoring dialogs. For both measures, the amount of cohesion in the tutoring dialog was found to be significantly correlated to learning for students with below-mean pretest scores, but not for those with above-mean pre-test scores, even though both groups had similar amounts of cohesion. We also find that ...

The psychosocial construct of “social cohesion,” understood as social behaviors indicating trust, reciprocity, and concern for the well-being of the members of one’s community, is the key determinant of health in the “income inequality and social cohesion model” model (Ref. 1, p. 211). Social cohesion is defined as participation in public affairs, civic responsibility or involvement in public l...

Analogously to chromosome cohesion in eukaryotes, newly replicated DNA in E. coli is held together by inter-sister linkages before partitioning into daughter nucleoids. In both cases, initial joining is apparently mediated by DNA catenation, in which replication-induced positive supercoils diffuse behind the fork, causing newly replicated duplexes to twist around each other. Type-II topoisomera...

This study introduces the Tool for the Automatic Analysis of Cohesion (TAACO), a freely available text analysis tool that is easy to use, works on most operating systems (Windows, Mac, and Linux), is housed on a user's hard drive (rather than having an Internet interface), allows for the batch processing of text files, and incorporates over 150 classic and recently developed indices related to ...

Class cohesion is a key attribute that is used to assess the design quality of a class, and it refers to the extent to which the attributes and methods of the class are related. Typically, classes contain special types of methods, such as constructors, destructors, and access methods. Each of these special methods has its own characteristics, which can artificially affect the class cohesion mea...