there is controversy in the literature regarding a number of topics related to anterior cruciate ligament (acl)reconstruction. the purpose of this article is to answer the following questions: 1) bone patellar tendon bone (bptb) reconstruction or hamstring reconstruction (hr); 2) double bundle or single bundle; 3) allograft or authograft; 4) early or late reconstruction; 5) rate of return to sp...

While airway endoscopy and bronchoalveolar lavage are the methodsof choice for diagnosing exercise-induced pulmonary hemorrhage (EIPH), these techniques do not allow accurate evaluation of the severity of bleeding. EIPH pathology is characterized by occlusive remodeling of pulmonary veins. Affected veins have large collagen deposits in their walls, which reduces their lumens. In the caudodorsal...

Type III neuregulins exposed on axon surfaces control myelination of the peripheral nervous system. It has been shown, for example, that threshold levels of type III beta1a neuregulin dictate not only the myelination fate of axons but also myelin thickness. Here we show that another neuregulin isoform, type III-beta3, plays a distinct role in myelination. Neuronal overexpression of this isoform...

Because of the value of cryoablation of the atrioventricular (AV) conduction system in treatment of refractory cardiac rhythm disorders, the anatomic effects of cryoablation on the cardiac conduction system must be defined. In this report we summarize studies done on four patients who had intractable recurrent supraventricular tachyarrhythmias or or refractory atrial flutter-fibrillation. They ...

This study was conducted on the atrioventricular node (AVN) and atrioventricular bundle (AVB) of fivefour-month-old ovine fetuses. The histological structure of these components was studied by routinehistological techniques and use of specific staining methods. The AVN was caudally located adjacent to theroot of the aorta. It was almost spherical in shape and consisted of twisty cells. The node...

BACKGROUND Tenocytes have been implicated in the development of tendinosis, a chronic condition commonly seen in musculoskeletal overuse syndromes. However, the relation between abnormal tenocyte morphology and early changes in the fibrillar collagen matrix has not been closely examined in vivo. Second harmonic generation (SHG) microscopy is a recently developed technique which allows examinati...

This study evaluates the tissue integration and collagen network effects of HA-based soft filler Juvéderm Voluma XC in a rat model using novel three-dimensional (3-D) imaging platform image analysis algorithms. Rats were injected subcutaneously with 125 μL XC. After 4- or 12-weeks post-injection, second harmonic generation (SHG) signal autofluorescence within entire bolus was assessed TissueVis...

INTRODUCTION: The anterior cruciate ligament (ACL) is composed of two bundles. Those two bundles show different tensioning patterns from knee extension to flexion. The purpose of this study was to clarify the differences in ultrastructure between the anteromedial bundle (AMB) and the posterolateral bundle (PLB) of the ACL using transmission electron microscope (TEM). Our hypothesis was that fun...

The study of the organizational kinetics in area surrounding transmucosal part dental implants promises to ensure an accurate diagnosis healing process, terms osseointegration and long-term implant success. In this demonstrative work, morphological, qualitative quantitative characteristics 3D images collagen bundles obtained by synchrotron-based high-resolution X-ray tomography were analyzed. D...

A factory needs a good distribution pipeline for its products, and so does a cell that manufactures collagen. Wilson et al. (1) describe a protein that helps pack several varieties of collagen into vesicles so they can be shipped from the cell. Collagen was one of the fi rst proteins identifi ed, but researchers are still trying to elucidate the mechanics of its secretion. After their synthesis...