BACKGROUND Coronary collaterals are an alternative source of blood supply to myocardium jeopardized by ischaemia. Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival. METHODS AND RESULTS Collateral arteries preventing myocardial ischaemia during brief vascular occlusion are present in 1/3 of patients with...

This paper examines how a shock to collateral value, caused by asset market fluctuations, influences the debt capacities and investments of firms. Using a source of exogenous variation in collateral value provided by the land market collapse in Japan, I find a large impact of collateral on the corporate investments of a large sample of manufacturing firms. For every 10 percent drop in collatera...

OBJECTIVE We attempted to investigate the potential association between leptin and coronary collateral vessel development in patients with non-ST elevation acute coronary syndromes (NSTE-ACS). METHODS One hundred and nineteen consecutive patients with NSTE-ACS with high-grade coronary stenosis or occlusion in at least one epicardial coronary artery were prospectively enrolled in a cross-secti...

This study was performed to test the hypothesis that active constriction of coronary collateral vessels can worsen hypoperfusion of collateral-dependent myocardium during exercise. Studies were performed in seven adult mongrel dogs in which intermittent followed by permanent occlusion of the left circumflex coronary artery produced an area of collateral-dependent myocardium without gross eviden...

Collateral status is an independent predictor of stroke outcome. However, the spatiotemporal manner in which collateral flow maintains cerebral perfusion during cerebral ischemia is poorly understood. Diabetes exacerbates ischemic brain damage, although the impact of diabetes on collateral dynamics remains to be established. Using Doppler optical coherent tomography, a robust recruitment of lep...