In response to chronic treatment with furosemide, collecting ducts adapt their function to the initial loss of Na+ to prevent further Na+ loss and extracellular volume decrease. This adaptation, which includes the overexpression of Na+, K+-ATPase, is thought to account for most of the kaliuretic effect of furosemide. Because piretanide is reported to be less kaliuretic than equidiuretic doses o...

In this paper, we give the first online algorithms with a polylogarithmic competitive ratio for the node-weighted prize-collecting Steiner tree and Steiner forest problems. The competitive ratios are optimal up to logarithmic factors. In fact, we give a generic technique for reducing online prize-collecting Steiner problems to the fractional version of their non-prize-collecting counterparts lo...

Over 26,000 manuscripts have been published dealing with endothelins since their discovery 25 years ago. These peptides, and particularly endothelin-1 (ET-1), are expressed by, bind to, and act on virtually every cell type in the body, influencing multiple biological functions. Among these actions, the effects of ET-1 on arterial pressure and volume homeostasis have been most extensively studie...

In this paper, we reduce Prize-Collecting Steiner TSP (PCTSP), Prize-Collecting Stroll (PCS), Prize-Collecting Steiner Tree (PCST), Prize-Collecting Steiner Forest (PCSF) and more generally Submodular Prize-Collecting Steiner Forest (SPCSF) on planar graphs (and more generally bounded-genus graphs) to the same problems on graphs of bounded treewidth. More precisely, we show any α-approximation ...

The Comprehensive Child Development Program (CCDP) was a two-generation program that employed case management and home visiting to assure low-income children and their parents of a range of educational, health, and social services. Designed to meet the complex needs of disadvantaged families, CCDP was predicted by its planners to generate positive short- and long-term effects across a variety o...

the increase in water demand and its services due to population growth and the raising of the standards of living, health, and hygiene along with the limitation of water resources, droughts, and climate change has attracted water specialists and planners to explore the use of unconventional water resources, such as sewage and saline waters. moreover, industrial and rural wastewater disposal and...

Recently, the use of overexpression of telomerase reverse transcriptase (TERT) has led to the generation of immortalized human cell lines. However, this cell immortalization approach has not been reported in well-differentiated mouse cells, such as renal epithelial cells. We sought to establish and then characterize a mouse collecting duct cell line, using ectopic expression of mTERT. Isolated ...

Prior RNA sequencing (RNA-seq) studies have identified complete transcriptomes for most renal epithelial cell types. The exceptions are the cell types that make up the renal collecting duct, namely intercalated cells (ICs) and principal cells (PCs), which account for only a small fraction of the kidney mass, but play critical physiological roles in the regulation of blood pressure, extracellula...