PURPOSE Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional characterization of NI in colon cancer. EXPERIMENTAL DESIGN NI was investigated in 673 patients with colon cancer. Localization and severity of NI was determined and related to patient's prognosis and survival. The neuro-affinity of...

Background: Colon cancer is one of the most diagnosed cancers in modern world. Chemotherapy relevant treatments for colon cancer, but this method treatment has severe and sometimes irreversible side effects. Therefore, alternative with fewer effects are highly considered. Natural herbal medicine been proven to be a great source these methods. Objectives: This study aimed investigate anti-prolif...

constipation isa common clinical problem that can be functional or organic in origin. thiscondition sometimes overlaps with irritable bowel syndrome. initially, theclinician should differentiate between true and false constipation by clinicaland preclinical evidence such as colonic transit time. numerous patients believethat all defecation problems are called constipation and use laxatives with...

The effects of 6-gingerol on adhesive ability probiotics to colonic epithelial cells in vitro were explored. Two strains Lactophilus acidophilus and Bifidobacterium bifidum. NCM 460 (normal cells) Caco-2 (colon cancer used this study. Effect (5, 10, 15, 20, 25, 30, 35, 40 ?g/mL effect (10, 50, 75, 100, 125, 150, 175 ?g/mL) investigated. MTT assay was adopted analyze cell proliferation. Methods ...

objective(s):transforming growth factor-β(tgf-β) is involved in colorectal cancer (crc). the sd-208 acts as an anti-cancer agent in different malignancies via tgf-β signaling. this work aims to show the effect of manipulation of tgf-β signaling on some mirnas implicated in crc. materials and methods: we investigated the effects of sd-208 on sw-48, a colon adenocarcinoma cell line. the cell line...

background: improvement in complications of antitumor agents and surgery is important to enhance life quality and survival among patients with colon and colorectal cancer. it has been reported that some dietary components such as glutamine (gln) have beneficial effects on these complications of cancer therapies. however, the results of studies are inconsistent in this area. we performed a revie...

Cancer deaths increase every year, including in Indonesia. The low selectivity of chemotherapy agents and the resistance cancer cells against is main cause treatment failure. It causes serious side effects sufferers. Beside that, plants produce secondary metabolites which are being investigated for anticancer activity that used as new clinical drugs. Therefore we need research uses co-chemother...

objective: the purpose of this study was to observe the effects of methoxyamine (mx) on the cytotoxic effects and dna damage caused by 5-fluorouoracil (5-fu), in combination with gamma-rays in human colon cancer cell line. materials and methods: in this experimental study, ht29 cells were cultured as a monolayer and treated with different concentrations of 5-fu along with 1 mm mx for 24 h. afte...

Although CD133 has been reported to be a promising colon cancer stem cell marker, the biological functions of CD133+ colon cancer cells remain controversial. In the present study, we investigated the biological differences between CD133+ and CD133- colon cancer cells, with a particular focus on their interactions with cancer-associated fibroblasts, especially CD10+ fibroblasts. We used 19 prima...