PURPOSE The objective of this study was to prepare a suitable form of nanofiber for indomethacin using polymers Eudragit RS100 (ERS) and Eudragit S100 (ES) and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. METHODS Electrospinning process was used for preparation of nanofibers. Different solutions of combinations of ERS, ES and indomethacin ...

Acute colonic pseudo-obstruction (ACPO) can occur as a potential complication following various surgical procedures. Whereas several cases of ACPO are documented in the medical literature following Caesarean section (C-section), only rarely has it been described in association with a normal vaginal delivery. We report a 32-year-old female who developed acute intestinal obstruction immediately f...

rug delivery to the colon is beneficial not only for the oral delivery of proteins and peptide drugs (degraded by digestive enzymes of stomach and small intestine) but also for the delivery of low molecular weight compounds used to treat diseases associated with the colon or large intestine such as ulcerative colitis, diarrhea, and colon cancer. In addition, the colon has a long retention time ...

Apatinib is an oral tyrosine kinase inhibitor, which selectively targets vascular endothelial growth factor receptor 2 and has the potential to treat many tumors therapeutically. Cyclic arginylglycylaspartic acid (cRGD)- and polyethylene glycol (PEG)-modified liposomes (cRGD-Lipo-PEG) were constructed to act as a targeted delivery system for the delivery of apatinib to the human colonic cancer ...

Isolated perfused segments of pig ileum and sigmoid colon were used as an extrinsically denervated model of intestinal fluid propulsion to compare the effects of intraluminal (IL) with intraarterial (IA) administration of cisapride and mebeverine. The ileal segments had a spontaneous mean activity of 0.008 (SEM 0.003) ml Krebs propelled aborally min-1, with propulsive waves at a mean frequency ...

We examined the hypothesis that exogenous stimulation with physiological doses of 3,5,3'-triiodothyronine (T(3)) and/or norepinephrine at birth can improve thermoregulation in near-term lambs delivered by cesarean section. This was achieved by investigating the effect of delivery temperature [i.e., warm (30( degrees )C) vs. cool (15( degrees )C) ambient temperatures] on hormonal stimulation on ...

Natural products have limitation in the bioavailability of active components because numbers reasons which includes poor solubility ingredient, stability due to gastric and colonic acidity, metabolism by effect gut microflora, absorption across intestinal wall, efflux mechanism first-pass metabolic effects these factors make failure clinical trials efficacy natural phytochemicals used for human...