Serial sections of 812 rectal biopsy specimens from 356 Crohn's disease patients were analysed for mucosal epithelial dysplasia. Dysplasia was found in 18 patients (5%), with four showing dysplasia on repeat biopsy specimen. In these 22 biopsy specimens the dysplasia was mild in 13, moderate in nine, and severe in none. Subsequently, three patients (17%) developed neoplasms including carcinoma ...

Objective We investigated whether dual-time-point 18-Fluorodeoxyglucose (18FDG) positron emission tomography/computed tomography (PET/CT) could improve the positive predictive value for detecting advanced colorectal neoplasms (cancer, adenoma ≥10 mm or adenoma with high-grade dysplasia). Methods We retrospectively searched for consecutive patients with a known primary cancer, who had a colonic ...

Cystic sebaceous neoplasms have been seen only in patients with Muir-Torre syndrome (MTS) and have recently been characterized as marker lesions of MTS. Histologically, these lesions form a spectrum of tumors ranging from benign cystic adenomas to proliferative cystic sebaceous tumors. We describe 2 proliferative cystic sebaceous tumors in a 53-year-old man whose workup revealed colonic adenoca...

Introduction. Neuroendocrine neoplasms (NENs) of the gastrointestinal tract (GIT) are slow-growing and rare tumors with different clinical, histological, biological characteristics an increased incidence in recent years. Most them indolent colonic NENs among all GIT-NENs. Compared to colorectal adenocarcinoma neuroendocrine colon sigmoid uncommon. Case outline. We present a 25-year-old female p...

We have reported protective effects of dietary administration of a powder "CHRP" containing high amounts of beta-cryptoxanthin and hesperidin prepared from a Satsuma mandarin (Citrus unshiu Marc.) juice on azoxymethane (AOM)-induced rat aberrant crypt foci through suppression of crypt cell proliferation and/or induction of detoxifying enzymes. In the present study, we investigated the modifying...

PURPOSE Inflammation influences carcinogenesis. In the current study, we investigated whether ursodeoxycholic acid (UDCA) can inhibit colitis-related mouse colon carcinogenesis and compared it with the effects of sulfasalazine. EXPERIMENTAL DESIGN Male CD-1 mice were given a single i.p. injection of azoxymethane followed by 1-week oral exposure of 1% dextran sodium sulfate in drinking water. ...

background and objectives: gastrointestinal polyps are proliferative or neoplastic mucosal lesions. the most important point about these polyps is risk of malignancy of them. this study was performed to determine type and frequency of polyps of gastrointestinal tract in iranian population according to their locations. materials and methods: totally, 210 patients referred to rasul-e-akram hospi...

Any two or more primary malignant tumors, in which each tumor is not an extension, recurrence, metastasis of the other lesion, are defined described as multiple neoplasms (MPMN). These tumors increasingly diagnosed despite their rare occurrence rate. The term synchronous applied if different originating same patient detected at time within six months; second beyond months, it called metachronou...