Thirty-seven patients suffering from vertigo associated with vertebrobasilar insufficiency participated in our prospective, single-center, double-blind, comparative study. Patients were randomly allocated to treatment with placebo; betahistine (12 mg betahistine dimesylate, one tablet three times daily); or the fixed combination of 20 mg cinnarizine and 40 mg dimenhydrinate (one tablet three ti...

For colonic drug delivery, the ascending part of colon is most favourable site as it offers suitable environmental conditions for dissolution. Commonly, performance a formulation assessed using standardised dissolution apparatus, which does not replicate hydrodynamics and shear stress evoked by wall motion in colon. In this work, computer simulations are used to analyse understand influence dif...

till date, most of the drugs have been given in conventional immediate release dosage form. nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

aluminum phosphide (alp) as 3 g tablet is widely used in iran to protect stored food grains from pests. hyperglycemia following its ingestion has been already reported in the recent years but severe hypoglycemia is uncommon. here, we report a 19 year old male who attempted suicide with one tablet of alp and demonstrated severe hypoglycemia. despite restoration of blood glucose concentration to ...

OBJECTIVES Simplification of antiretroviral therapy enhances a patient's adherence but a new formulation could also lead to new adverse events and changes in daily routine. This study compared medication adherence, tolerance and satisfaction among subjects switching from a two-tablet tenofovir/emtricitabine/efavirenz regimen to a one-tablet regimen. METHODS Clinical and sociodemographic data ...

In the coming years, farmers will have to deal with growing crops under suboptimal conditions dictated by global climate changes. The application of plant biostimulants such as beneficial microorganisms and plant-derived protein hydrolysates (PHs) may represent an interesting approach for increasing crop tolerance to alkalinity and salinity. The current research aimed at elucidating the agronom...

AIMS Two tablet formulations of buprenorphine (a buprenorphine mono-product, Subutex, and a buprenorphine/naloxone combination product, Suboxone) are available for use in the treatment of opioid addiction; however, the bulk of the clinical studies supporting its approval by the US Food and Drug Administration (FDA) were conducted with a sublingual liquid preparation. To assist the clinician in ...

N THE LAST DECADE, UBIQUITOUS computing has moved from a futuristic vision to a reality. As computing power continues to increase and hardware becomes more compact, computers have become part of our work and social life, anywhere and anytime. Benefiting from the combination of wireless connectivity and portability similar to that of a traditional spiral notebook, the tablet PC is allowing peopl...

BACKGROUND Alternatives to the available stavudine-containing paediatric fixed-dose combination (FDC) tablets are rapidly needed due to concerns regarding the cumulative toxicity of long-term stavudine exposure. We report the bioavailability and short-term safety of a novel paediatric FDC tablet of zidovudine (ZDV)/lamivudine (3TC)/nevirapine (NVP; 30/15/28 mg) in HIV-infected children. METHO...

propranolol, a prototypical b-adrenergic receptor antagonist and atenolol, a cardio-selective b-antagonist are widely used in therapeutic regimens for treatment of hypertensive patients. in iran, several pharmaceutical manufacturers formulate these two b-blockers. as the formulation of a dosage form is essential for the patient's safety and drug efficacy, in this study we aimed to evaluate...