We present PyQUBO, an open-source Python library for constructing quadratic unconstrained binary optimizations (QUBOs) from the objective functions and constraints of optimization problems. PyQUBO enables users to prepare QUBOs or Ising models various combinatorial problems with ease thanks abstraction expressions extensibility program. formulated using are solvable by machines, including quant...

Protein tyrosine phosphatases, SH2 and PTB domains are crucial elements for cellular signal transduction and regulation. Much effort has been directed towards elucidating their specificity in the past decade using a variety of approaches. Combinatorial library methods have contributed significantly to the understanding of substrate and ligand specificity of phosphoprotein recognizing domains. T...