chelating is the chemical process by which a mineral (iron, cobalt, copper, zinc, and manganese) is combined with a mixture of amino acids and peptides. the resulting substances are known as chelates. another descriptive term, proteinates, refers to the amino acid bond. these chelated minerals are thought to be more digestible than nonchelated forms. in other words, chelation makes the minerals...

background and objectives: in the original in vitro method for evaluation of iron bioavailability using caco-2 cell model, ferritin formation by cells is considered as a functional indicator of both absorption and utilization of iron. however, as iron is measured in the tested material and then ferritin concentration is measured in caco-2 cell lysate, it is almost impossible to have a concrete ...

several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine which bi...

To assess the comparative bioavailability of two cyclosporine capsule products with different pharmaceutical formulation an open randomized two-period cross over study was conducted in 24 healthy volunteers. Our results, obtained from cyclosporine HPLC determination onto the whole blood samples collected, show that the test cyclosporine non-SMEDDS formulation was not bioequivalent cyclosporine ...

Egg albumin microspheres containing pilocarpine nitrate were prepared by heat stabilization method. Factors affecting size and encapsulation efficiency were optimized to obtain microspheres in the size range 1 to 12 μm to make them undetectable by eyes and big enough to entrap drug efficiently. Encapsulation efficiency was found to be 62.5%. In vitro release of drug from microspheres followed s...

PURPOSE Pressurized metered dose inhalers are commonly used in patients with asthma. However, the need to coordinate inhalation with inhaler actuation means that they are not suitable for use per se. Valved holding chamber devices were developed to overcome some of the problems of pressurized metered dose inhalers. Several types of holding chambers of different sizes are available in Iran. This...

curcumin is a hydrophobic polyphenol and major bioactive component of turmeric with known anti-inflammatory, neurogenesis, antioxidant, and anti-carcinogenic effect. curcumin antagonizes many steps in the inflammatory cascade, including inhibition of nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells), activator protein-1 transcription and inos (induced nitric oxide synthases...

due to poor solubility in lipids, many of bioactive components (nutraceutical materials) show less bioactivity than optimal state in water solution. phytosomes improve absorption and bioavailability of biomaterials. liposomes, spherical shaped nanocarriers, were discovered in the 1960s by bangham. due to their composition, variability and structural properties, liposomes and phytosomes are extr...

the mobility and bioavailability of trace elements in the agricultural soils are extremely important in assessing the risk of toxicity to the growing plants. a five step sequential extraction procedure (sep) has been employed to study the speciation of as, sb, cr, cu, cd, pb, zn, ni, fe and mn in 18 soil samples neighboring an industrial complex in isfahan, central iran. enrichment factor (ef) ...

Consumption of flaxseed lignans is associated with various health benefits; however, little is known about the bioavailability of purified lignans in flaxseed. Data on their bioavailability and hence pharmacokinetics (PK) are necessary to better understand their role in putative health benefits. In the present study, we conducted a comparative PK analysis of the principal lignan of flaxseed, se...