To better understand the role of nutrition in regulating mammary gland development and lactation, we designed a novel stair-step compensatory nutrition regimen that is a unique combination of dietary energy restriction and realimentation (refeeding) phases; the basic concept of this regimen is to exploit the biological nature of the compensatory growth phenomenon in concert with one or more hor...

Synthesis and remodeling of the lung matrix is necessary for primary and compensatory lung growth. Because cyclic negative force is applied to developing lung tissue during the respiratory cycle, we hypothesized that stretch is a critical regulator of lung matrix remodeling. By using quantitative image analysis of whole-lung and whole-lobe elastin in situ zymography images, we demonstrated that...

Although a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface receptors to the intracellular signaling cascades provided an important step forward. Moreover, Insulin/IGF receptors use common signaling pathways to accomplish many tasks, the IRS proteins add a unique laye...

Hsia, Connie C. W. Signals and mechanisms of compensatory lung growth. J Appl Physiol 97: 1992–1998, 2004; doi:10.1152/japplphysiol.00530.2004.— Growth of the lung involves unique structure-function interactions not seen in solid organs. Mechanical feedback between the lung and thorax constitutes a major signal that sustains developmental as well as compensatory lung growth. After the loss of l...

Several studies have demonstrated that poor early nutrition, followed by growth compensation, can have negative consequences later in life. However, it remains unclear whether this is attributable to the nutritional deficit itself or a cost of compensatory growth. This distinction is important to our understanding both of the proximate and ultimate factors that shape growth trajectories and of ...

In many animal taxa, size-selective predation favors fast growth early in life. However, same-aged juveniles can diverge in size due to differences in genotype, environmental conditions, and parental effects and thus may vary in competitive ability. Under food scarcity, competitively inferior juveniles may suffer suppressed growth, whereas under benign conditions, small juveniles may exhibit gr...

COMPENSATORY GROWTH IN DOUBLE MUSCLED BULLS 1 2 3 Different Periods of Feed Restriction Before Compensatory Growth in Belgian Blue Bulls: 4 II. Plasma Metabolites and Hormones 5 6 J. L. Hornick, C. Van Eenaeme, M. Diez, V. Minet, and L. Istasse. 7 8 9 10 Department of Nutrition, Veterinary Faculty, Sart Tilman 11 B43 4000 Liège, Belgium 12 13 Phone: 32-(0)4-3664139 14 Fax: 32-(0)4-3664122 15 E-...

The capacity of skeletal and cardiac muscle to increase in size in response to increased physiological demand is well known. However, little is known of either the biochemical mechanisms involved in this compensatory hypertrophy or the cellular and physiological changes resulting from this growth process. Studies of protein synthesis during work-induced hypertrophy are relevant to such question...

Partial lung resection initiates compensatory growth of remaining lobes to restore pulmonary structure and function. Mechanisms underlying this response are not well defined. This article considers molecular pathways involved in control of amphibian limb regeneration and tissue pattern formation for novel insight into the understanding of compensatory lung growth.