was not generated in this three-way translocation. Translocation t(8;18;16)(p11;q21;p13), another three-way translocation variant of t(8;16)(p11;p13) found in a 15month-old boy with AML M5b, also has a structure that could not generate CBP-MOZ but MOZ-CBP, while RTPCR was not performed in this case. Moreover, Murati et al. reported a 72-year-old man with AML M5a having a complex t(8;16)(p11;p13...

One of the goals in long-term cares for patients with diabetes mellitus (DM) is to prevent the development of micro-and macrovascular complications (The International Diabetes Federation, 2011). To achieve this purpose, an adequate control of blood pressure (BP) as well as a good glycaemic control is crucial (The International Diabetes Federation, 2011). The American Diabetes Association recomm...

Both the amino-terminal and carboxyl-terminal domains of IGF binding protein (IGFBP)-3 are believed to contribute to high-affinity IGF binding. To investigate cooperativity in IGF binding by these domains, we expressed IGFBP-3 fragments 1-88 (NBP-3) and 185-264 (CBP-3) as FLAG and hexahistidine-tagged fusion proteins, respectively. IGF-I and IGF-II bound to NBP-3 poorly and to CBP-3 with modera...

Forkhead box class O 3a (FOXO3a) is a transcription factor and tumor suppressor linked to longevity that determines cell fate through activating transcription of cell differentiation, survival, and apoptotic genes. Recruitment of the coactivator CBP/p300 is a crucial step in transcription, and we revealed that in addition to conserved region 3 (CR3) of FOXO3a, the C-terminal segment of CR2 (CR2...

Circulating insulin-like growth factor 1 (IGF-1) has been shown to act as a negative feedback regulator of growth hormone (GH) gene expression; however, the mechanism of this negative feedback is poorly understood. Activation and regulation of GH gene expression require the binding of the transcription factor POU1F1 to the GH promoter along with cyclic AMP (cAMP) response element binding protei...

Previous longitudinal studies have demonstrated that blood pressure measurements at home (HBP) in the wakening-up display stronger predictive power for death, and vascular complications in patients with type 2 diabetes mellitus (T2DM) than clinic blood pressure measurements (CBP). The leading cause of death was cancer. Patients with T2DM have associated with cancer, and high CBP is a risk facto...

Gaofen-3 (GF-3) is China' first C-band multi-polarization synthetic aperture radar (SAR) satellite, which also provides the sliding spotlight mode for the first time. Sliding-spotlight mode is a novel mode to realize imaging with not only high resolution, but also wide swath. Several key technologies for sliding spotlight mode in spaceborne SAR with high resolution are investigated in this pape...

The p300 and CBP transcriptional coactivator paralogs (p300/CBP) regulate a variety of different cellular pathways, in part, by acetylating histones and more than 70 non-histone protein substrates. Mutation, chromosomal translocation, or other aberrant activities of p300/CBP are linked to many different diseases, including cancer. Because of its pleiotropic biological roles and connection to di...

DSP-based chromatic dispersion compensation accounts for a large part of the overall power dissipation in fiber-optic receiver ASICs. We have implemented and evaluated compensation filters based different design methods using a MATLAB-based coherent fiber-optic system model in respect to compensation performance, filter length, and fixed-point aspects. Possible power savings when taking into ac...