Seventy-three consecutive patients with complex tibial fractures treated with an Ilizarov frame or Taylor Spatial Frame received physiotherapy between April 2008 and April 2010. Data were collected prospectively, and physiotherapy input was recorded (in minutes) for the patients identified. This included treatment received as an inpatient as well as an outpatient. The data were categorized for ...

Introduction Citicoline is a complex organic molecule that functions as an intermediate in the biosynthesis of cell membrane phospholipids. Citicoline is also known as CDP-choline and cytidine diphosphate choline (cytidine 5’-diphosphocholine). CDP-choline belongs to the group of biomolecules in living systems known as “nucleotides” that play important roles in cellular metabolism. CDP-choline ...

CCAAT-displacement protein/Cut homeobox (CDP/Cux) was initially identified as a transcriptional repressor. However, a number of studies have now suggested that CDP/Cux is a transcriptional activator as well. Stable DNA binding activity of CDP/Cux is up-regulated at the G(1)/S transition by two mechanisms, dephosphorylation by the Cdc25A phosphatase and proteolytic processing to generate a 110 k...

PURPOSE A prospective evaluation was undertaken to assess the efficacy of intensive, short-term decongestive lymphatic therapy coupled with focused patient instruction in long-term self-care for the management of lymphedema. METHODS The therapeutic responses of 79 patients with lymphedema were analyzed prospectively. Each patient received intensive, short-term decongestive lymphatic therapy, ...

Gemcitabine 5'-diphosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication and repair. The Escherichia coli RNR, an alpha2beta2 complex, when incubated with 1 equiv of F(2)CDP catalyzes the release of two fluorides and cytosine concomitant with enzyme inactivation. In the prese...

BACKGROUND E-learning is a common and popular mode of educational delivery, but little is known about its effectiveness in teaching practical skills. The aim of this study was to determine whether the Physiotherapy eSkills Training Online resource in addition to usual teaching improved the performance of practical skills in physiotherapy students. METHOD This study was a non-randomised contro...

INTRODUCTION: Secondary lymphedema is a chronic and debilitating complication of breast cancer therapy affecting more than one in five breast cancer survivors.1 In this patient population, patient-reported outcomes may be more important in predicting long-term health-related quality of life (HRQoL) than clinician measured outcomes.2 Cost-effectiveness analysis can be used to compare different t...

Crude extracts of Salmonella fyphi catalyze the conversion of cytidine diphosphate D-glucose to CDP-tyvelose. Two intermediates in this reaction sequence have been identitied as CDP-4-keto-6-deoxyglucose and CDP-paratose. The enzyme catalyzing the conversion of CDP-D-glucose to CDP-4-keto-6-deoxyglucose (CDP-n-glucose oxidoreductase) has been purified approximately 50-fold from these extracts, ...