We construct a graph complex calculating the integral homology of the bordered mapping class groups. We compute the homology of the bordered mapping class groups of the surfaces S1,1, S1,2 and S2,1. Using the circle action on this graph complex, we build a double complex and a spectral sequence converging to the homology of the unbordered mapping class groups. We compute the homology of the pun...

The accurate display of high dynamic range images requires the application of complex tone mapping operators. These operators are computationally costly, which prevents their usage in interactive applications. We propose a general framework that delivers interactive performance to an important subclass of tone mapping operators, namely global tone mapping operators. The proposed framework consi...

The nuclear pore complex (NPC) mediates transport between the nucleus and cytoplasm. By the late 1990s, components of the NPC, known as nucleoporins, were being discovered at a steady rate, but researchers believed that many more might remain to be identifi ed. After all, a ribosome consists of 75 proteins, and an NPC, with a molecular weight of 50 MDa, is more than ten times as large. Still le...

Genetic linkage analysis is the primary method for the identification of loci contributing to complex disease susceptibility. Linkage analysis techniques can be applied to both disease status (discrete traits) and to quantitative trait measures (quantitative trait loci or QTL mapping). Such techniques will be most effective if they can be applied to all of the available data; in human, ecologic...

Genome-wide association studies (GWAS) have identified thousands of robust and replicable genetic associations for complex disease. However, the identification of the causal variants that underlie these associations has been more difficult. This problem of fine-mapping association signals predates GWAS, but the last few years have seen a surge of studies aimed at pinpointing causal variants usi...

Admixture mapping is a popular tool to identify regions of the genome associated with traits in a recently admixed population. Existing methods have been developed primarily for identification of a single locus influencing a dichotomous trait within a case-control study design. We propose a generalized admixture mapping (GLEAM) approach, a flexible and powerful regression method for both quanti...

SUMMARY FunMap is a Web-based user interface designed to map quantitative trait loci (QTL) affecting function-valued traits or infinite-dimensional traits in well-structured pedigrees or natural populations. User input includes three files: longitudinal trait data, marker genotypes and/or a linkage map. This software allows for a systematic genome-wide scan and significance test of QTL througho...

Genome-wide association studies have become a standard tool for disease gene discovery over the past few years. These studies have successfully identified genetic variants attributed to complex diseases, such as cardiovascular disease, diabetes and cancer. Various statistical methods have been developed with the goal of improving power to find disease causing variants. The major focus of this d...