Objective Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several strategies for the simultaneous analysis of function and mortality in ALS clinical trials. Meth...

OBJECTIVE To determine the relationship between margin preparation design and resin-composite type on microleakage with or without re-application of surface-penetrating sealant. METHODS Class-I resin-composite restorations were completed for 128 extracted human molars. Half of the margins were beveled, the other half, butt-joint. Half of each group was restored with Filtek-Supreme (FS), the o...

The use of composite structures is increasingly present in civil construction works. Steel-concrete composite beams, particularly, are structures consisting of two materials, a steel section located mainly in the tension region and a concrete section, located in the compression cross sectional area , both connected by metal devices known as shear connectors. The main functions of these connecto...

A systematic and affordable approach is proposed for the robust design of thick laminated composite structures. Our approach integrates the principles of the Robust Concept Exploration Method (RCEM) for designing complex engineering systems and the hierarchical multi-level optimization procedure for managing the complexity of composite structure optimization. Foundational to the proposed approa...

We introduce a new approach for part-based human pose estimation using multi-layer composite models, in which each layer is a tree-structured pictorial structure that models pose at a different scale and with a different graphical structure. At the highest level, the submodel acts as a person detector, while at the lowest level, the body is decomposed into a collection of many local parts. Edge...

During 1996–2006 the Ministry of Agriculture and Forestry in Finland, MTT Agrifood Research Finland and the Finnish Geodetic Institute carried out a joint remote sensing satellite research project. It evaluated the applicability of composite multispectral SAR and optical satellite data for cereal yield estimations in the annual crop inventory program. Three Vegetation Indices models (VGI, Infra...

AMPTIAC Directory ... 15 The beginning In late 1993, the Mechanics and Surface Interactions Branch of the Air Force Research Laboratory’s Materials Directorate (AFRL/MLBM) was tasked to investigate the accuracy of the analysis methods used to predict the strength of bolted composite joints used on high-performance fighter aircraft such as the F-22 Raptor. The strength of bolted joints is essent...

In this paper a robust composite control algorithm is proposed for flexible joint manipulators, with the emphasis on satisfying control effort limitations. An H∞ framework is used for the slow subsystem controller design, instead of robust PID synthesis introduced in the literature. Linear identification techniques are used to represent the nonlinear dynamics of the system into a linear model p...