We examine theoretically the effect of bismuth chalcogenide microparticles on spontaneous emission a double-V-type quantum emitter in free space. have found, particular, that presence single microparticle causes high degree interference way releases energy process emission. This, turn, leads to significant changes spectrum emitted energy. The emitter’s initial state is crucial how released micr...

RATIONALE Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. OBJECTIVE To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. METHODS AND RESULTS We measured a comprehensive panel of circulating cell-derived microparticles by a sta...

BACKGROUND Formal validation of methods for biospecimen processing in the context of accreditation in laboratories and biobanks is lacking. A protocol for processing of a biospecimen (urine) was validated for fitness-for-purpose in terms of key downstream endpoints. METHODS Urine processing was optimized for centrifugation conditions on the basis of microparticle counts at room temperature (R...

This study answered the question of whether biophysical mechanisms for microparticle shedding discovered in platelets and erythrocytes also apply to nucleated cells: cytoskeletal disruption, potassium efflux, transbilayer phospholipid migration, and membrane disordering. The calcium ionophore, ionomycin, disrupted the actin cytoskeleton of S49 lymphoma cells and produced rapid release of microp...

BACKGROUND Plasma can be manufactured by multiple methods. Few studies have compared quality parameters between plasma products that may affect efficacy and safety. METHODS Four different plasma products were analyzed to include fresh frozen plasma (FFP), liquid plasma (LP), solvent detergent plasma (SDP), and a spray-dried, solvent detergent-treated plasma (SD-SDP) at multiple time points of...

BACKGROUND Shiga toxin-induced haemolytic uraemic syndrome (STEC-HUS) is an acute multisystem disorder characterized by renal failure, neurological dysfunction, haemolysis and intravascular thrombosis. Circulating microparticles originating from a number of cell types including thrombocytes and leucocytes are elevated in paediatric patients. In vitro data also suggest modification of leucocyte ...

We have earlier shown that microglia, the immune cells of the CNS, release microparticles from cell plasma membrane after ATP stimulation. These vesicles contain and release IL-1beta, a crucial cytokine in CNS inflammatory events. In this study, we show that microparticles are also released by astrocytes and we get insights into the mechanism of their shedding. We show that, on activation of th...

t Microparticless are membrane vesicles released from many different cell types. There are two mechanismss that can result in their formation, cell activation and apoptosis. In both these mechanismss different pathways are involved in microparticle generation. Microparticle generationn seems to be a highly regulated process that results in formation of microparticles that varyy in size, phospho...

the delivery of therapeutic proteins has gained momentum with development of biotechnology. however, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (git) resulted in low absorption. the main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhgh) on the basis of parti...