background: the aim of this study was to determine the microtensile bond strength (μtbs) of ceramic and composite computer aided design‑computer aided manufacturing (cad‑cam) blocks bonded to dentin using different adhesive strategies. materials and methods: in this in vitro study, 30 crowns of sound freshly extracted human molars were sectioned horizontally 3 mm above the cementoenamel junctio...

LAI-YUEN, SUSANA KARINA. Nano-scale Molecular Docking and Assembly Simulator (NanoDAS) with Haptic Force-Torque Rendering and Energy Minimization for ComputerAided Molecular Design (CAMD). (Under the direction of Dr. Yuan-Shin Lee). The objective of this research is to investigate and develop computational and haptic interface techniques to improve the search and design of molecular docking, an...

BACKGROUND Diabetes is a metabolic disorder that requires multiple therapeutic approaches. The pancreas loses its functionality to properly produce the insulin hormone in patients with diabetes mellitus. In 2012, more than one million people worldwide died as a result of diabetes, which was the eighth leading cause of death. OBJECTIVE Most drugs currently available and approved by the U.S. Fo...

Checkpoint kinase 1 (Chk1) is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative str...