The shape of the dose-response curve may vary depending on whether one examines response at a population or a single cell level. Populations of cells may exhibit a graded response whereas single cell responses may have threshold or switch-like behavior. Studies in vivo and in vitro using primary hepatocyte cultures have shown that induction of CYP1A1 in the liver exhibits switch-like behavior i...

BACKGROUND The most common measure to compare potencies of volatile anesthetics is minimum alveolar concentration (MAC), although this value describes only a single point on a quantal concentration-response curve and most likely reflects more the effects on the spinal cord rather than on the brain. To obtain more complete concentration-response curves for the cerebral effects of isoflurane, sev...

• In the usual procedure for determination of indicator dilution curves, the sensing or measuring device is placed at some distance from the sampling site. The fluid is transported by a sampling system, usually a cathe-ter, from the withdrawal site to the sensing point. This sampling system always introduces some distortion in the time-concentration curve, so that the recorded curve is not the ...

Submit Manuscript | http://medcraveonline.com Abbreviations: SB: Solvent-Based; Nab-Paclitaxel: AlbuminBound Paclitaxel; FDA: Food and Drug Administration; DHA: Dubai Health Authority; DH: Dubai Hospital; MTD: Maximum Tolerated Dose; AUC: Concentration-Time Curve; PFS: Progression-Free Survival; OS: Overall Survival; ORR: Objective Response Rate; ECOG: Eastern Cooperative Oncology Group; RECIST...

Signals from resistive gas sensors based on zirconium dioxide and silicon–carbon films have been extensively investigated to estimate concentration. In this study, the change in normalized resistance of sensor’s response under NO2 exposure is shown analysis first second derivatives curves were carried out. A signal-processing scheme, reducing effect noise signal drift, proposed. The extreme der...

This study evaluated the possible contribution of gap junctions to the nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses elicited by bradykinin in bovine pulmonary supernumerary arteries. In artery rings with an intact endothelium and treated with the cyclo-oxygenase inhibitor indomethacin (10 microM), bradykinin (100 pM-1 microM) produced a concentrati...

The effect of changing extracellular pH was studied on the currents induced by ATP or alphabeta-methylene-ATP in HEK293 cells transfected with different P2X receptor subunits. In cells expressing P2X1, P2X3, or P2X4 receptors, the effect of ATP was decreased by acidification. In cells expressing P2X2 receptors, acidification increased the ATP-induced current; this effect was also seen in cells ...