Several quinones have been found to be effective in the treatment of some forms of cancer; however, their cumulative heart toxicity limits their use. The cannabinoid quinone HU-331 [3S,4R-p-benzoquinone-3-hydroxy-2-p-mentha-(1,8)-dien-3-yl-5-pentyl] is highly effective against tumor xenografts in nude mice. We report now a comparison of the anticancer activity of HU-331 and its cardiotoxicity w...

BACKGROUND An aim of the National Primary Care Collaborative is to improve quality and access for patients in primary care using principles of Advanced Access. AIMS To determine whether Advanced Access led to improved availability of appointments with general practitioners (GPs) and to examine GPs' views of the process. DESIGN Observational study. SETTING Four hundred and sixty-two genera...

Recent findings on the inhibition of angiogenesis and vascular endothelial cell proliferation by anthracycline antibiotics, which contain a quinone moiety, make this type of compound a very promising lead in cancer research/therapy. We have reported that a new cannabinoid anticancer quinone, cannabidiol hydroxyquinone (HU-331), is highly effective against tumor xenografts in nude mice. For eval...

Abstract Aim Drives towards ambulatory management in emergency surgery have resulted increased availability of urgent imaging to expedite decision making. This review CT usage aimed assess frequency surgical pathology identified, and subsequent management. Methods All acute general referrals an established clinic between 01/01/2021 22/07/2022 were included. Information regarding presentation, i...

The aim of this paper is to discuss what sort of baryon-number violating process arise on the supersymmetric versions of the model based on the gauge group SU(3)C ⊗SU(3)L⊗U(1)N . We discuss the mechanism of baryon number violation which induces proton decay, and derive bounds on the relevant couplings. [email protected]

Cannabidiol, the major nonpsychotropic phytocannabinoid, has been recently demonstrated to induce apoptosis in primary lymphocytes via an oxidative stress-dependent mechanism. Cannabidiol can be converted by microsomal enzymes to the hydroxyquinone metabolite HU-331 that forms adducts with glutathione. The present study tested the hypothesis that HU-331 could cause apoptosis via the depletion o...

Anthracyclines, a large group of quinonoid compounds, are used to treat some forms of cancer. Although highly effective in cancer therapy, the mechanism of action of these compounds is not specific; they act on cancer and other cells by numerous mechanisms. A new anticancer quinone (HU-331) was synthesized from cannabidiol. It shows significant high efficacy against human cancer cell lines in v...

Let µ 1 (G) ≥. .. ≥ µn (G) be the eigenvalues of the adjacency matrix of a graph G of order n, and G be the complement of G. Suppose F (G) is a fixed linear combination of µ i (G) , µ n−i+1 (G) , µ i G ¡ , and µ n−i+1 G ¡ , 1 ≤ i ≤ k. It is shown that the limit lim n→∞ 1 n max {F (G) : v (G) = n} always exists. Moreover, the statement remains true if the maximum is taken over some restricted fa...

Si(331)-(12x1) is the only confirmed planar silicon surface with a stable reconstruction located between (111) and (110). We have optimized the annealing sequence and are able to obtain almost defect free, atomically precise surface areas approaching micrometer dimensions. The unprecedented perfection of the surface combined with its pronounced structural anisotropy makes it a promising candida...