A bioequivalence study of two verapamil formulations (generic verapamil tablets and Isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. Moreover, the feasibili...

Correspondence K. Krishnamoorthy, Department of Mathematics, University of Louisiana at Lafayette, Lafayette, LA 70504, U.S.A. Email: [email protected] The problems of finding confidence limits for the mean and an upper percentile, and upper prediction limits for the mean of a future sample from a gamma distribution are considered. Simple methods based on cube root transformation and fiduci...

This paper deals with a situation of some importance for the analysis of experimental data via Neural Network (NN) or similar devices: Let N data be given, such that N = Ns +Nb, where Ns is the number of signals, Nb the number of background events, both unknown. Assume that a NN has been trained, such that it will tag signals with efficiency Fs, (0 < Fs < 1) and background data with Fb, (0 < Fb...

The use of confidence intervals has become standard in the presentation of statistical results in medical journals. Calculation of confidence limits can be straightforward using the normal approximation with an estimate of the standard error, and in particular cases exact solutions can be obtained from published tables. However, for a number of commonly used measures in epidemiology and clinica...