The pathogenesis of congenital hypothyroidism due to thyroid dysgenesis is still unknown. A point mutation in the TSH receptor (TSHR) of the hypothyroid hyt/hyt mouse invoked the TSHR as a candidate gene for congenital hypothyroidism. Therefore, we screened for mutations in the TSHR gene in patients with congenital hypothyroidism and hypoplasia of the gland. In one girl detected in neonatal scr...

this study was aimed to evaluate the situation of congenital hypothyroidism (ch) in guilan using the screening program and determine the correlation of ch with birth weight, gestational age and seasonality. during 2006 to 2010, in guilan province, neonatal screening for ch by measurement of serum tsh level was performed in 3-5 days after birth. all neonates with tsh level ≥ 5mu/l were referred ...

Three patients with congenital goitrous hypothyroidism are reported. They were treated with adequate thyroxine replacement and developed well defined microfollicular thyroid adenomas despite being euthyroid clinically and biochemically throughout their clinical course. Patients with congenital goitrous hypothyroidism appear to be at increased risk of developing thyroid adenoma in childhood desp...

A congenital hypothyroidism complicated by ventricular septal defects which was treated with L-triiodothyronine (L-T3) alone from 1 5/12 to 25 years, is described. The patient's growth and development was satisfactory and without side effects. It suggests that L-T3 may be a safe drug for long term treatment of congenital hypothyroidism.

s, International symposium onenvironmental life elements and health.Beijing: Academy of Sciences, 1988: 283.27.Tarim OF, Yordam N: Congenital hypothy-roidism in Turkey: a retrospective evaluationof 1000 cases. Turk. J. Pediatr. 1992; 34(4):197-202.28.Tsai WY, Lee JS: Congenital hypothyroidismin Taiwan: experience before mass screening.J. Formosan Med. Assoc. ...

On the basis of strong clinical evidence, congenital hypothyroidism should be identified and treated early to avoid potentially profound cognitive deficits. On the basis of strong clinical evidence, the dose of levothyroxine is higher at early ages and progressively decreases into adulthood. On the basis of observational studies and consensus, children with congenital hypothyroidism and a eutop...

Background: Congenital hypothyroidism (CH), as one of the most common congenital endocrine disorders, may be significantly associated with congenital malformations. This study investigates urogenital abnormalities in children with primary CH (PCH). Methods: This case-control study was conducted on 200 children aged three months to 1 year, referred to Amir-Kabir Hospital, Arak, Iran. One hund...

context appropriate management of neonates, tested positive for congenital hypothyroidism (ch), in particular, the initial dosage of levothyroxine and the time of initiation of treatment is a critical issue. the aim of this study was to assess all current evidence available on the subject to ascertain the optimal initial dose and optimal initiation time of treatment for children with ch. eviden...

OBJECTIVES To determine the prevalence of congenital hypothyroidism in children with filter-paper blood-spot TSH (b-TSH) between 5 and 10μIU/mL in the neonatal screening. METHODS This was a retrospective study including children screened from 2003 to 2010, with b-TSH levels between 5 and 10μIU/mL, who were followed-up during the first two years of life when there was no serum TSH normalizatio...