In 1973, Robertson' introduced the term macroaneurysm to describe large aneurysms arising on a main retinal arteriole within the first three orders of bifurcation. Retinal arteriolar macroaneurysms occur primarily in elderly people with hypertensive and generalised arteriosclerotic vascular disease. 1-8 The condition may be the result of aging, hypertension, and arteriosclerosis.' Local damage ...

We report a 6-month-old boy who presented with unilateral leukocoria, retinal detachment, and a retrolental mass in a microphthalmic eye based on retinal dysplasia with concurrent optic nerve aplasia. Dysplastic retinal tissue, a rare congenital defect, may create a clinical and radiologic picture of an intraocular mass closely resembling tumor tissue. MR imaging findings with histopathologic c...

BACKGROUND Ocular disease is a frequent manifestation of congenital Toxoplasma gondii infection. There are only limited data available in the literature concerning early stages of this disease in fetuses and infants. The purpose of our study was to characterize histopathological features in the eyes of 10 fetuses and 2 infants with congenital toxoplasmosis. METHODS Fifteen eyes from 10 fetuse...

Most individuals with congenital nystagmus (CN) do not complain of oscillopsia (visual inconstancy) even though the amount of retinal image slip varies considerably according to gaze angle and CN waveform. We induced oscillopsia in four subjects with CN by artificially stabilizing images upon the retina under several conditions. Every subject reported oscillopsia during retinal image stabilizat...

Fanconi anemia (FA) is a genetic disease in which the bone marrow cannot produce enough blood cells, included group of hereditary failure syndromes. In addition to congenital genitourinary, gastrointestinal, neurodevelopmental, and ophthalmological problems, it may be associated with acquired conditions such as increased cancer risk retinal occlusive vasculopathy. This article aims present macu...

Two patients with congenital retinoschisis developed rhegmatogenous retinal detachments with either a tractional component or associated vitreous haemorrhage. The second patient also had a large, raised schisis cavity under vitreous traction, which obscured visualisation of the macula. Vitrectomy is indicated for some patients with congenital retinoschisis.

PURPOSE Butterfly-shaped macular dystrophy (BSMD) has so far only been associated with mutations in the peripherin/RDS gene. The initial aim of our study was to investigate the peripherin/RDS gene as the causative gene in a family with BSMD. Subsequently the putative involvement of the ROM-1 gene, 4 genes expressed in cone photoreceptors, all known non-syndromic macular, retinal pigment epithel...

PURPOSE To identify patients with autosomal recessive retinal dystrophy caused by mutations in the gene, retinal dehydrogenase 12 (RDH12), and to report the associated phenotype. METHODS After giving informed consent, all patients underwent full clinical evaluation. Patients were selected for mutation analysis based upon positive results from the Asper Ophthalmics Leber congenital amaurosis a...

PURPOSE To evaluate the clinical features and functional and anatomical outcomes after surgical intervention in pediatric rhegmatogenous retinal detachment. METHODS In this retrospective case series, pediatric patients with rhegmatogenous retinal detachment who had surgical intervention were included. Cases were categorized into five main etiology groups: congenital or developmental (48 eyes)...