AIM To investigate the association of human immunodeficiency virus (HIV) infection and carcinoma of the conjunctiva in Africa, and the role of human papilloma virus type 16 (HPV-16). METHODS Patients in Uganda and Malawi presenting to eye clinics with lesions suspicious of carcinoma were studied. Pathological confirmation of eye lesions was sought. HIV testing of patients who were biopsied an...

PURPOSE To evaluate topical interferon alpha-2b (IFNalpha2b) as a lone therapy in the treatment of primary conjunctival and corneal intraepithelial neoplasia (CIN). METHODS Noncomparative, prospective, interventional case series. Seven patients from three institutions, treated between February and October 1999, with presumed primary CIN lesions (clinically diagnosed by corneal specialists) we...

Cutaneous leishmaniasis is a parasitic hyperendemic disease in Isfahan. Its lesions can be solitary or multiple depending on the number of insect bites and is usually seen exposed areas. The possibility of insect bite on palpebral area is rare due to the protection by eyelashes and palpebral motion. In this area, lesions are usually presented as chalazion, dacryocystitis and rarely ulcera...

Metastatic disease is linked to TERT promoter mutations in conjunctival melanomas (CM). Both and ATRX are associated with faulty telomere maintenance. This study aimed determine the prognostic value of loss melanocytic lesions. Eighty-six lesions from Rotterdam Ocular Melanoma Study group were collected. status determined using immunohistochemical staining molecular diagnostics, respectively. N...

BACKGROUND Conjunctival myxomas are rare, benign, connective tissue tumours that classically present as slow-growing, painless, well-circumscribed masses (Arch Ophthalmol 124:735-8, 2006; Case Rep Ophthalmol 3:145-50, 2012). There have been 29 cases reported in the literature (Arch Ophthalmol 124:735-8, 2006; Malays J Med Sci 20(1):92-4, 2013; Case Rep Ophthalmol 3:145-50, 2012; Middle East Afr...

OBJECTIVE To report clinical, histopathological and molecular features of 'salmon patch'-like conjunctival lesions in paediatric and adolescent patients, and discuss management of these patients and outcome. METHODS Patients who presented between 2000 and 2011 with a conjunctival 'salmon-patch'-like lesion in the plical area, were identified by chart review. Clinical parameters, demographic c...

BACKGROUND Conjunctival amyloidosis is a very rare condition, generally unilateral, and presents mostly as an isolated condition without systemic compromise. Our purpose is to present a new case of systemic amyloidosis with a bilateral conjunctival involvement. CASE PRESENTATION A 66-years-old caucasian female complaining of conjunctival hemorrhage and chemosis in both eyes for the last five ...

OBJECTIVE To report a previously unrecognized benign bilateral widespread conjunctival and corneal proliferative condition with a potential to affect vision. METHODS A gradually progressive diffuse conjunctival proliferation extending on the cornea was noted in 14 patients (28 eyes). These patients were followed up for a mean of 6 years for the site, extent, and progression of the condition. ...

CLINICAL CASE The case of a 60 year-old male with a conjunctival lesion diagnosed as conjunctival intraepithelial neoplasia (CIN), who was treated with mitomycin-C for 3 weeks with minimal improvement. The therapy was change to interferon 2B. Six month later, and after a complete remission of the lesion, the treatment was suspended, with no signs of relapse. DISCUSSION The treatment of these ...

This is a preliminary report of a rapid and easy method of confirming the diagnosis in patients with suspected sarcoidosis. Isolated cases of conjunctival sarcoidosis have been described from time to time, but the condition hasgenerally been believed to be quite rare (Woods, 1951). On the contrary, we have so often found it in patients with generalized sarcoidosis that conjunctival biopsy would...