This paper reports on results of intracytoplasmic sperm injection (ICSI) in patients in whom constitutional or secondary chromosome aberrations were detected in the male and/or female partner. Out of 434 couples treated by ICSI (590 cycles), 16 couples (3.7%) were affected by constitutional chromosome aberrations and 96 (22.1%) by secondary chromosome aberrations. Constitutional chromosome aber...

Schwannomatosis is a form of Neurofibromatosis type 2 (NF2) characterized by multiple schwannomas without vestibular involvement, affecting the cranium, spine and periphery. Several recent genetic studies have implicated the SMARCB1/INI1 tumour suppressor gene in familial schwannomatosis. SMARCB1 is located centromeric to NF2 on 22q and loss of function of SMARCB1 is also a hallmark of malignan...

IN THE REALM OF CONSTITUTIONAL LAW, feder-alism can be classified as a perennial issue, its history predating the adoption of the constitution itself.' Federalism conveys both a sense of structure and a sense of mandate, and while it is not as constant a presence in constitutional jurisprudence as issues affecting individual rights, it is a concept, nevertheless, which is a deeply rooted one, f...

Theories of political entrepreneurship usually focus on the construction of coalitions necessary to change policy. We argue that political entrepreneurs who are unable to secure favored policies may redirect their efforts to a “higher tier,” attempting to change the rules of the game to enable the exploitation of future political profit opportunities. We present a taxonomy of three levels of po...

All legal transplants are problematic, constitutional transplants especially so. And constitutional transplants for federal systems are among the most problematic of all. Still, especially in light of the apparent derailing of the EU’s Draft Constitutional Treaty, the question of the relevance of EU constitution-making for constitution-making in federal-style systems elsewhere seems nothing les...

The Sasang constitutional medicine (SCM), a medical tradition originating from Korea, is distinguished from the traditional Chinese medicine in its philosophical background, theoretical development and especially, the fundamental rationale that analyzes the structure and function of the human body within a quadrifocal scheme. In SCM, the structure of the body is comprehended within the Sasang q...

16 proportionality” which the German Constitutional Court developed in the 1950s and which since then has been treated as unwritten constitutional law in Germany. In the decades that followed the 1950s the German Constitutional Court realized that the principle of proportionality (commensurability) works like a representation of people’s moral sense and sense of justice. Therefore, the German C...