Ingestion of even small amounts of MDMA ('ecstasy') by a small subset of the population may result in a potentially fatal clinical syndrome of severe hyperpyrexia, cardiovascular collapse, coagulopathy, rhabdomyolysis and multiple organ failure. Rapid and aggressive temperature control is of utmost importance in the management of these patients. We report a case of MDMA toxicity presenting with...

The evidence for using pulmonary arterial hypertension (PAH) therapies such as prostacyclin derivatives, endothelin receptor antagonists and type-5 phosphodiesterase inhibitors in pulmonary veno-occlusive disease (PVOD) is modest and conflicting [1, 2]. Indeed, despite several reports of clinical deterioration and life-threatening pulmonary oedema in PVOD patients receiving PAH therapies, we ha...

This is a report of skin necrosis following a leakage of intravenous infusion of 5% sodium bicarbonate injection during the treatment of continuous veno-venous hemodialysis (CVVHD) in a female patient. The patient sequentially suffered from systemic capillary leak syndrome (SCLS), severe sepsis, and multiple organ dysfunction syndromes (MODS). She died due to refractory septic shock and MODS. B...

A patient with rheumatoid arthritis developed hepatic veno-occlusive disease following the use of azathioprine. Although azathioprine induced veno-occlusive disease is suspected to occur more frequently in patients with autoimmune dysfunction, it has not previously been reported as a complication of treatment in rheumatoid arthritis. The mechanism responsible for this condition remains unknown.