BACKGROUND Topiramate is a broad-spectrum agent effective against primarily generalized tonic-clonic seizures (PGTCS) as well as partial-onset seizures. Juvenile myoclonic epilepsy is one of the most common idiopathic generalized epilepsies, with most patients experiencing PGTCS. OBJECTIVE To evaluate topiramate as add-on therapy in patients with juvenile myoclonic epilepsy. DESIGN Post-hoc...

We report a 9-year-old boy with history of Angelman syndrome (AS) associated epilepsy, behavioral issues, intellectual disability, and sleep disturbance. Genetic testing revealed methylation imprinting defect, thereby confirming the diagnosis AS. His seizures were well-controlled on monotherapy clobazam he underwent routine EEG (figure), which showed notched delta pattern.

The ketogenic diet has been used for the treatment of epilepsy in children for almost 100 years. Originally, it was determined that individuals with seizures found benefit from starvation; subsequently a diet was proposed which was high in fat content, the breakdown of fat for energy producing ketones and therefore mimicking starvation(1). This was subsequently found to be effective in treating...

The elderly population faces an increasing number of cases of chronic neurological conditions, such as epilepsy and Alzheimer's disease. Because the elderly with epilepsy are commonly excluded from randomized controlled clinical trials, there are few rigorous studies to guide clinical practice. When the elderly are eligible for trials, they either rarely participate or frequently have poor adhe...

Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There is still no approved medication for the treatment of this problem. Objectives: The present study aims to assess the safety and efficacy of memantine in improving the cognitive function of patients with epilepsy. Materials & Methods: This is a pilot, randomized, double-blind, placebo-controlle...

PURPOSE To investigate response to sequential treatment schedules and risk of development of refractory epilepsy in childhood. METHODS All children younger than 14 years with two or more unprovoked seizures seen at our hospital between 1994 and 2004 were included and prospectively followed. "Seizure control" was defined as a 2-year seizure-free interval without further recurrences except thos...

Yoga is an age-old traditional Indian psycho-philosophical-cultural method of leading one's life, that alleviates stress, induces relaxation and provides multiple health benefits to the person following its system. It is a method of controlling the mind through the union of an individual's dormant energy with the universal energy. Commonly practiced yoga methods are 'Pranayama' (controlled deep...

People with epilepsy suffer from a considerable lack of physical activity. In addition, an important problem of epilepsy management is the lack of qualified professionals. In this study we present data from a survey which aimed to assess physical educators' general knowledge about epilepsy. One hundred and thirty four physical educators of both sexes answered a questionnaire. Sixty percent of t...