Purpose: This study aimed to evaluate the effect of controlled hypotension on cerebral oxygen saturation and postoperative cognitive dysfunction (POCD) in patients undergoing nasal surgery.
 Materials Methods: Forty were randomized by a sealed envelope method into two drug groups: esmolol (Group E, n=20) or nitroglycerin N, administration prior surgical incision. The functions evaluated Mi...

BACKGROUND AND AIMS Controlled hypotension with balanced anaesthesia minimises blood loss. This study was done to evaluate the effectiveness of intravenous clonidine as a single bolus dose to establish controlled hypotension during functional endoscopic sinus surgery (FESS). METHODS This randomised, double-blind, placebo-controlled study was done in a tertiary hospital in India. Sixty America...

Sir,—Dr Collier is disappointed that we did not comment on e.c.g. changes during hypotension. Alas, we cannot remedy this because no such changes occurred. A continuous recording was taken in each case and none showed any arrhythmia. If she has evidence that changes in rhythm during hypotension indicate cardiac hypoxia and a low cardiac output (and "considered by some" hardly rates as evidence)...

We evaluated the effects of isoflurane anaesthesia and induced hypotension in 33 neurosurgical patients by electrocardiographic monitoring and serial cardiac enzyme measurements. An electrocardiogram (ECG) and serum enzymes were obtained preoperatively, intraoperatively and postoperatively in the recovery room and for three consecutive days. ECG leads II, V1 and V5 were monitored continuously d...

Postural hypotension resulting from 2 mg. of intramuscular atropine appears to be due to peripheral vascular pooling. Controlled studies on 31 normal adult males are reported here and reveal that external compression of the abdomen and lower extremities allows partial cardiovascular compensation. Simultaneous compression of both legs and abdomen is even more effective in preventing postural hyp...

crossover study, clonidine, 0.3 mg/day orally for 3 days, significantly reduced systolic and diastolic blood pressure and heart rate, whereas placebo was ineffective. Naloxone, 0.4 mg given intravenously on the third day of clonidine treatment, caused a rapid increase in blood pressure and heart rate in 14 patients (reacting group), but was ineffective in the remaining 13 patients (nonreacting ...

Central haemodynamics and regional blood flow were investigated during and after sodium nitroprusside (SNP) infusion in halothane anaesthetized rats. The administration of SNP 40 micrograms kg-1 min-1, decreased mean arterial pressure (MAP) to 52 (mean) mm Hg. Cardiac output (CO) remained unchanged, while heart rate (HR) and systemic vascular resistance (SVR) decreased. The regional blood flow ...