abstractvarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (slns). due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. different strategies have been employed to overcome this problem. in this direction, the present study introduces erodible in-situ forming gel systems ...

in this research, hydrogels based on poly vinyl alcohol and poly acrylic acid blend were prepared which were cross-linked by applied thermal conditions. afterward, effects of time and heating on water uptake were investigated. the highest water uptake value exhibited by the sample that was heated for 20 min. at 110 ºc was about 2129% after 4 days at equilibrium state. hydrogels exhibited ph-sen...

preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of nile red-loaded solid lipid nanoparticles. nanoparticles (nps) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. to solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

microencapsulation has become a common technique in the production of controlled release dosage forms. many results have been reported, concerning the use of alginate beads as controlled release drug formulations. alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...