doi: 10.1111/j.1399-3054.2007.00879.x The most abundant copper proteins in green tissues are plastocyanin (PC) in thylakoids and copper/zinc superoxide dismutase (Cu/ZnSOD) of which the major isoforms are found in the cytosol and in the chloroplast stroma. An iron superoxide dismutase (FeSOD) can also be found in the stroma. The expression of superoxide dismutases (SODs) has been studied mainly...

The relative influence of protein unfolding on the Cu(I) affinity of trafficking and target sites for copper has been determined. For the copper metallochaperone Atx1 from Synechocystis PCC 6803 (a cyanobacterium), Saccharomyces cerevisiae and humans unfolding in urea results in a decrease in the Cu(I) affinity from (4-5) × 10(17) M(-1) to (1-3) × 10(16) M(-1) at pH 7. The affinities of the unf...

Copper (Cu) is an essential trace element for all aerobic organisms. It functions as a cofactor in enzymes that catalyze a wide variety of redox reactions due to its ability to cycle between two oxidation states, Cu(I) and Cu(II). This same redox property of copper has the potential to cause toxicity if copper homeostasis is not maintained. Studies suggest that the toxic properties of copper ar...

Stable-isotope studies in human infants and adults have shown that copper homeostasis occurs, but the contribution of the small intestine to this regulation is still not well understood. Copper first needs to be reduced to the cuprous form, most likely by Steap proteins on the apical membrane. Copper is subsequently absorbed by Ctr1 and then transferred in the enterocyte by the chaperone Atox1 ...

Speciation of copper in the channels of MCM-41 during reduction of NO with CO at 473-773 K was studied by in situ extended X-ray absorption fine structural (EXAFS) and X-ray absorption near edge structural (XANES) spectroscopies in the present work. The component fitted (in situ) XANES spectra of the catalyst showed that about 72% of metallic copper (Cu(0)) in MCM-41 was oxidized to higher oxid...

this study was conducted to determine the effects of different levels and sources of copper supplementation on hematological values, ceruloplasmin and plasma copper, zinc and iron status in mehraban male lambs. twenty growing lambs were randomly allotted to four different treatments. treatments consisted of 1) 10 mg/kg cu in the form of cuso4, 2) 20 mg/kg cu in the form of cuso4, 3) 10 mg/kg cu...

Copper resistance has emerged as an important virulence determinant of microbial pathogens. In Streptococcus pneumoniae, copper resistance is mediated by the copper-responsive repressor CopY, CupA and the copper-effluxing P(1B)-type ATPase CopA. We show here that CupA is a previously uncharacterized cell membrane-anchored Cu(I) chaperone and that a Cu(I) binding-competent, membrane-localized Cu...

There is increasing recognition that inflammatory liver disease in dogs is associated with abnormal hepatic copper (Cu) concentrations. Abnormal hepatic Cu accumulation results as either a primary metabolic defect in Cu metabolism unique to some breeds or as a secondary event associated with chronic hepatic cholestasis resulting in a decrease in biliary excretion of hepatic Cu. Abnormal hepatic...

Copper is one of the oldest known metals used by humans. It was discovered around 9000 BC, and was first used to make metal tools and weapons. Medical applications of copper were known to the ancient Egyptians and Greeks. The metal has widespread and varied uses in modern society. Thus copper has played an important part in human cultural evolution, but the element has a much more ancient role ...

Copper particles were incorporated into nanofibers during the electrospinning of poly-D,L-lactide (PDLLA) and poly(ethylene oxide) (PEO). The ability of the nanofibers to prevent Pseudomonas aeruginosa PA01 and Staphylococcus aureus (strain Xen 30) to form biofilms was tested. Nanofibers containing copper particles (Cu-F) were thinner (326 ± 149 nm in diameter), compared to nanofibers without c...