Copper-β-amyloid 16 (Aβ16) complexes were investigated by electrospray ionization mass spectrometry (ESI-MS). Copper(i) and (ii) complexes were formed on-line in a microchip electrospray emitter by using a sacrificial copper electrode as the anode in positive ionization mode. In the presence of ascorbic acid in the peptide solution, the amount of Cu(i)-Aβ16 generated electrochemically was even ...

Copper-b-amyloid 16 (Ab16) complexes were investigated by electrospray ionization mass spectrometry (ESI-MS). Copper(I) and (II) complexes were formed on-line in a microchip electrospray emitter by using a sacrificial copper electrode as the anode in positive ionization mode. In the presence of ascorbic acid in the peptide solution, the amount of Cu(I)-Ab16 generated electrochemically was even ...

The influence of cation-π interactions on the electrochemical properties of copper(II) complexes with synthesized pentapeptide C-terminal fragment of Atrial Natriuretic Factor (ANF) hormone was studied in this work. Molecular modeling performed for Cu(II)-NSFRY-NH2 complex indicated that the cation-π interactions between Tyr and Cu(II), and also between Phe-Arg led to specific conformation defi...

The anticancer properties of pure copper (II) acetate and copper (II) acetylacetonate, alone and loaded on functionalized sol-gel titania (TiO(2)), were determined in four different cancer cell lines (C6, RG2, B16, and U373), using increasing concentrations of these compounds. The copper complexes were loaded onto the TiO(2) network during its preparation by the solgel process. Once copper-TiO(...

Three copper(ii) complexes with bidentate ligands L(1), L(2) and L(3) [L(1), N,N(/)-dimethylethylenediamine; L(2), N,N(/)-diethylethylenediamine and L(3), N,N(/)-diisobutylethylenediamine], respectively, were synthesized as their perchlorate salts. The single crystal structures for all the complexes were determined. The nitric oxide reactivity of the complexes was studied in acetonitrile solven...

Reactive methylene group at C2 position in dimedone plays an important role in the synthesis of a variety of organic ligands. Condensed compounds 3, 5, 7 were synthesized by reaction with dimedone and different aromatic aldehydes. Synthesized condensed compounds 3, 5 and 7 were on reaction with hydroxyl amine hydrochloride to yield oximes ligands 8, 9 and 10 respectively. The synthesized oxime ...

MALDI-TOF mass spectrometry, 1H NMR spectrometry, the continuous variation method and molecular modeling by MM3 calculation confirmed our earlier studies showing that gonadotropin-releasing hormone (GnRH) forms complex with copper(II) ion with the binding ratio 1:1. The copper(II) complex formed at physiological pH has a square planar configuration and GnRH complexes with nickel(II) and cobalt(...

Copper complexes of [Cu(phen)(tda)].2H2O(1) and [(phen)2Cu(µ-tda) Cu(phen)](ClO4)2.1.5H2O (2) (where phen is 1,10-phenanthroline and tda2- is thiodiacetate) have been synthesized. Both complexes were characterized by elemental analysis, IR, UV–Vis spectroscopy and cyclic voltammetry. Their solid state struct...

A series of imino- and amino-pyridine ligands based on dihydrobenzofurobenzofuran (BFBF) and methanodibenzodioxocine (DBDOC) backbones have been synthesized. These ligands form exclusively dinuclear complexes with metals such as iron(II) and copper(II). The structures for complexes 15, 16, 18, 19, 20, 21, 23, and 24 were determined by X-ray crystallography. The complexes show large distances fo...

In this paper, CuO nanoparticles  have been synthesized via solid- state thermal decomposition using copper(II) Schiff base complexes as new precursors at 600ºC under air atmosphere for 3 h. Surface morphology of the products were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM).