Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of ...

purpose: to evaluate the effect of topical phenytoin 1 % on corneal epithelial defects healing in a rabbit model. methods: one eye of 20 albino rabbits in the animal house of al-zahra ophthalmology hospital was studied. a single corneal epithelial defect was created. the rabbits were randomly assigned into two groups (ten animals in each group). after creating a chemical burn in rabbits, one gr...

PURPOSE To evaluate the activity of recombinant adenovirus encoding human vasohibin-1 (Ad-Vasohibin-1) on mouse corneal neovasularization induced by alkali burn. METHODS For the treatment group, 50 mice each received subconjunctival injection (5 microl) of 10(9) plaque forming units of replication-defective Ad-Vasohibin-1. Control group mice received the same dosage of blank adenoviral vector...

Corneal transparency relies on the precise arrangement and orientation of collagen fibrils, made mostly Type I V fibrils proteoglycans (PGs). PGs are essential for correct fibrillogenesis maintaining corneal homeostasis. We investigated spatial temporal distribution glycosaminoglycans (GAGs) after a chemical injury. The composition chondroitin sulfate (CS)/dermatan (DS) heparan (HS) were charac...

PURPOSE To explore the feasibility of bone marrow mesenchymal stem cells (MSCs) transdifferentiating into corneal epithelial cells in a limbal stem cell deficiency (LSCD) model in rats. METHODS Rat MSCs were isolated and purified using a gradient isolation procedure. The cells were induced by rat corneal stromal cells (CSCs) in a transwell co-culture system. The induced MSCs were identified b...

Purpose The purpose of this study was to investigate the role of substance P (SP) in patients affected with corneal neovascularization (CNV) and in three different Tac1-knockout (KO) murine models of CNV. Methods SP levels in tears were measured with a multiplex bead assay. The extent of human CNV was quantified as number of affected corneal quadrants. Murine CNV was induced in both strains b...