Clinical and biochemical manifestations of lecithin-cholesterol acyltransferase (LCAT) deficiency include an abnormal lipid profile (characterized by hypercholesterolemia with markedly decreased high-density lipoprotein cholesterol [HDL-C] and hypertriglyceridemia), corneal opacities, hematologic abnormalities (normochromic anemia of varying intensity), splenomegaly, variable early coronary art...

PURPOSE To report the observation of a triple corneal dystrophy association consisting of keratoconus (KC), epithelial basement membrane corneal dystrophy (EBMCD) and Fuchs' endothelial corneal dystrophy (FECD). METHODS A 55-year-old male patient was referred to our cornea service for blurred vision and recurrent foreign body sensation. He reported bilateral recurrent corneal erosions with di...

Superficial granular corneal dystrophy (SGCD) is a variant of GCD that is restricted to involvement of the Bowman layer and the superficial corneal stroma. Superficial and classic GCD result from mutations in the human transforming growth factor –induced gene (BIGH3) on human chromosome 5 (5q31). We report an unusual case of a patient with SGCD in which the typical deposits of GCD were associat...

Descemet stripping automated endothelial keratoplasty (DSAEK) is a new treatment option for corneal endothelial dysfunction. Compared with penetrating keratoplasty, DSAEK is less invasive and leads to more rapid visual recovery. The most common complications after DSAEK described in the literature are graft detachment and/or dislocation, rejection, epithelial ingrowth, and pupillary block, all ...

Five patients with the bradycardia-tachycardia syndrome have been treated successfully with the antiarrhythmic agent amiodarone. Three patients were treated for over nine months and one of these patients had corneal micro deposits. One patient had to be taken off the drug because of side effects. Amiodarone should be tried in patients suffering from the bradycardia-tachycardia syndrome before r...

Two groups of volunteer subjects wearing extended-wear soft lenses were monitored over a period of 20 weeks. Of 6 factors measured only 1, corneal touch threshold, was found to show evidence of progressive change. However, a high incidence of lens surface deposits was encountered.

PURPOSE This study aimed to examine the effects of demographic, lens performance, and ocular surface response measures on contact lens-related discomfort and dryness, using a large contact lens study database. METHODS A total of 4164 records were extracted from a database of 220 subjects participating in 46 silicone hydrogel contact lens studies. Subjects discontinued lens wear for 24 hours a...

The aim of this study was to use Descemet's Stripping-automated Endothelial Keratoplasty (DSAEK) as a novel treatment to remove thioridazine corneal deposits. A 53-year-old female presented with a 3-month history of visual loss and glare. She had been taking thioridazine (100 mg/day for 1 year) for a psychiatric disorder. Dense yellowish-brown deposits had developed in the posterior stroma. Thi...