OBJECTIVE Hypertension is a major issue in public health, and the financial costs associated with hypertension continue to increase. Cost-effectiveness studies focusing on antihypertensive drug combinations, however, have been scarce. The cost-effectiveness ratios of the traditional treatment (hydrochlorothiazide and atenolol) and the current treatment (losartan and amlodipine) were evaluated i...

Airline rescheduling is a relatively new field in airline Operations Research but increasing amounts of traffic will make disturbances to the original schedule more frequent and more severe. Thus, the need to address the various problems arising from this situation with systematic, cost-efficient approaches is becoming more urgent. One such problem is crew rescheduling where after a disturbance...

This study aims to analyze the form of market structure in Fried Onion Industry Kuningan Regency and effect capital intensity as an indicator structure, Capital Labor Ratio (CLR), advertising industrial behavior, internal efficiency (Xeff) on Price Cost Margin (PCM) performance Regency. uses multiple linear regression quantitative analysis. Based research data analysis results, formed is monopo...

Methods The primary goal of the new RA is to implement the principle of economical production. This should be kept in mind, while interpreting its content, because the act allows one to approach to each drug individually. At the beginning one needs to find a comparator currently financed with the best outcomes/cost ratio. The next step is to search for RCTs proving the superiority of the propos...

It is known that the price of food influences the purchasing and consumption decisions of individuals; however, little work has examined if the price of healthier food relative to unhealthier food in an individual's neighborhood is associated with overall dietary quality while using data from multiple regions in the United States. Cross-sectional person-level data came from The Multi-Ethnic Stu...

We present an experimental study of the price-setting newsvendor problem, which extends the traditional framework by allowing the decision maker to determine both the selling price and the order quantity of a given item. We compare behavior under this model with two benchmark conditions where subjects have a single decision to make (price or quantity). We observe that subjects deviate from the ...

BACKGROUND The treatment of patients with metastatic melanomas that harbour BRAF V600E or V600K mutations with trametinib plus dabrafenib appears to be superior to treatment with vemurafenib alone. This treatment regimen is likely to become available in Switzerland in the near future. OBJECTIVES To determine the cost-effectiveness of trametinib plus dabrafenib. METHODS A Markov cohort simul...

Based on the observation that the transparency of an algorithm comes with a cost for the algorithm designer when the users (data providers) are strategic, this paper studies the impact of strategic intent of the users on the design and performance of transparent ML algorithms. We quantitatively study the price of transparency in the context of strategic classification algorithms, by modeling th...