Los cuidadores primarios informales (CPIs) de niños con Trastorno del Espectro Autista (TEA) tienen mayor riesgo padecer una sobrecarga percibida (SCP) elevada en comparación otro tipo discapacidad, por lo que conviene comprender los factores asociados a este fenómeno. El presente estudio tuvo el objetivo analizar la relación entre SCP y percepción CPIs sobre grado independencia TEA reciben sus...

Abstract Background Although chimeric antigen receptor (CAR)-T cell therapy has been remarkably successful for haematological malignancies, its efficacy against solid tumors is limited. The combination of CAR-T with immune checkpoint inhibitors (CPIs), such as PD-1, PD-L1, and CTLA-4 antibodies, a promising strategy enhancing the antitumor cells. However, because most patients acquire resistanc...

Relevance: Stomach cancer (SC) is one of the most common malignant neoplasms and ranks fifth in incidence worldwide. The only
 curative approach to localized SC radical surgery with or without prior chemotherapy. But chemotherapy main treatment method for metastatic locally advanced SC. In later stages SC, there high resistance chemotherapy; therefore, a need find modern treatment
 ap...

BACKGROUND Hookworm disease is a major global health problem and principal among a number of soil-transmitted helminthiases (STHs) for the chronic disability inflicted that impacts both personal and societal productivity. Mass drug administration most often employs single-dose therapy with just two drugs of the same chemical class to which resistance is a growing concern. New chemical entities ...

background and aim: ventilator-associated pneumonia (vap) is the second most common infection within intensive care units (icus). happening in patients requiring mechanical ventilation for more than 48 hours, the disease is associated with high morbidity and mortality. this study aims to compare the effects of matrica and chlorhexidine mouthwashes on the prevention of vap among patients hospita...

OBJECTIVE Ventilator-associated pneumonia (VAP) is an infection with high mortality and morbidity that prolongs the length of stay in the intensive care unit (ICU) and hospitalisation. VAP is one of the most common infections in critically ill patients. This study aimed to prospectively determine the VAP rate and associated factors in critically ill patients with intensive antibiotic usage duri...

BACKGROUND Aerosolized amikacin (AA) is a current option for the management of ventilator-associated pneumonia (VAP) caused by multidrug-resistant Gram-negative bacteria (MDR-GNB), as it is reported that AA could increase the alveolar level of the drug without increasing systemic toxicity. This study aimed to evaluate the efficacy and safety of AA as an adjunctive therapy for VAP caused by MDR-...

EDITORIAL During the past decade, remarkable efforts have been made to establish valid and reliable techniques for the diagnosis of ventilator-associated pneumonia (VAP). One of the most important findings consistently reported has been the limited value of traditional clinical criteria for the definition of pneumonia [1–3]. This has reinforced the need for the inclusion of additional diagnosti...