Because the match phase in OPS5-type production systems requires most of the system's execution time and memory accesses, we proposed hash-based parallel production systems, CPPS (Clustered Parallel Production Systems), based on the RETE algorithm for distributed memory parallel computers, or multicomputers to reduce such a bottleneck. CPPS was e ective in speeding up the match phase, but still...

For almost 30 years, studies have confirmed the effectiveness of cell-penetrating peptides (CPPs) in the facilitation of the intracellular delivery of various cargo molecules, including RNA, DNA, plasmids, proteins or nanoparticles, under in vitro and in vivo conditions. The cellular uptake of CPPs occurs via energy-dependent, as well as -independent mechanisms. In this relatively new direction...

BACKGROUND Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects many adult men worldwide. The currently available therapies offer little or no proven benefit for CP/CPPS. We designed this study to assess the efficacy of acupuncture therapy for the treatment of CP/CPPS. METHODS This study is designed as a randomized, sham acupuncture-controlled trial. We will compare patients wit...

Interest in cell-penetrating peptides (CPPs) as delivery agents has fuelled a large number of studies conducted on cultured cells and in mice. However, only a few studies have been devoted to the behaviour of CPPs in human tissues. Therefore, we performed ex vivo tissue-dipping experiments where we studied the distribution of CPP-protein complexes in samples of freshly harvested human tissue ma...

Abstract Cyber-Physical Production Systems (CPPS) form the basis of next industrial revolution. However, many manufacturing companies are reluctant to adopt this disruptive technology due a lack know-how and high project risk. In paper, we present development design tool that addresses common challenges CPPS engineering, including complexity collaborative, multidisciplinary nature engineering p...

BACKGROUND Qian-Yu decoction (QYD) is a traditional Chinese medicinal recipe composed of Radix astragali (Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge) P.K. Hsiao, Fabaceae ), Herba epimedii (Epimedium brevicornum Maxim., Berberidaceae), Herba leonuri (Leonurus japonicus Houtt., Lamiaceae), Cortex phellodendri (Phellodendron chinense Schneid., Rutaceae) and Radix achyranthis b...

Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) are generally defined as small cationic peptides with the ability to interact with lipidic membranes, in a process driven by electrostatic and hydrophobic processes. The interaction with CPPs is known to lead to its translocation across the membrane, while with AMPs lead to membrane damage. Here we present one synthetic anionic ...

Most studies concerned the possible causes, course, and potential markers of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), with some interesting new ideas. The mix of organisms, mainly bacteria, that live inside us is a hot research topic today, and now CP/CPPS researchers are looking at how the mix in both the gut and the urinary tract differs from normal in men with CP/CPPS. The...

Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases. The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications. CPPs are rich in basic amino acids such as arginine and lysine and are able to tra...

Confocal laser scanning microscopy (CLSM) is the most popular technique for mapping the subcellular distribution of a fluorescent molecule and is widely used to investigate the penetration properties of exogenous macromolecules, such as cell-penetrating peptides (CPPs), within cells. Despite the membrane-association propensity of all these CPPs, the signal of the fluorescently labeled CPPs did ...