Case presentation: 1: A boy with developmental delay and congenital macrocephaly, evolving dysphagia airway hypotonia. Complete exome sequencing was performed detection of pathogenic variant in the PTEN gene (c.737C>T). 2: Premature boy, delayed development departure, macrocephaly ephelides foreskin. He developed nodular hyperplasia ileum painful amplification syndrome pharmacoresistant pain. S...

regardless of severity, earlier intervention to correct hearing loss in children improves speech development and conversational abilities. a cross-sectional study was performed on 230 neonates who were at risk of hearing loss in tehran university of medical sciences hospitals between september 2000 and february 2002. hearing was examined before the 3rd month by auditory brainstem responses (abr...

Carotid-cavernous fistulas (CCF) are abnormal communications between the internal carotid artery and the cavernous sinus. Traumatic carotid-cavernous fistulae are rare potential complications of craniofacial trauma. Typical findings of CCF are proptosis, chemosis, headache, oculomotor or abducens nerve palsy, trigeminal pain and pulsating bruit over the temporal skull and the bulb. CCF are repo...

The pathophysiological mechanisms of myofascial temporomandibular disorders (TMD) are still under investigation. The hypothesis that TMD pain is caused by a generalized sensitization of higher order neurons in the nociceptive pathways combined with a decreased efficacy of endogenous inhibitory systems has recently gained support in the literature. This study was designed to further investigate ...

From the Craniofacial Pain and Headache Center, Tufts University School of Dental Medicine, Tufts Medical Center (S.J.S.); the Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, and the Harvard School of Dental Medicine (D.A.K., L.B.K.); and Harvard Vanguard Medical Associates (D.A.K.) — all in Boston. Address reprint requests to Dr. Kaban at the Department of Oral an...

Cannabinoid receptor agonists produce analgesia for pains of non-cranial origin. However, their effectiveness for craniofacial pains is currently unclear. In the present study, the cannabinoid CB1/CB2 receptor agonist, WIN 55,212-2 (WIN), was bath applied to the brainstem while activity of spinal trigeminal nucleus caudalis (Vc) neurons evoked by transcutaneous electrical stimulation was record...