Two pregnancies at risk for X-linked recessive Duchenne's muscular dystrophy were studied at 18 and 20 weeks. Fetal blood was obtained by placental aspiration for measurement of plasma creatine phosphokinase activity. Activity in the first fetus was 96 IU per liter, as compared to a control range of 0 to 150 IU per liter in 16 pregnancies not at risk for the disorder. The pregnancy continued, a...

Context: Oral squamous cell carcinomas develop from a premalignant lesion or condition, which are due to a variety of aetiological factors. Early detection of these are necessary to prevent them from developing into carcinomas which can increase the mortality and morbidity. There are a variety of possible aids like histopathology, Hstiochemistry and Enzyme assays in diagnosing these lesions. Hi...

AIMS To determine if cardiac enzymes measured at necropsy could be used to predict early myocardial infarction. METHODS Cardiac enzyme activities were measured in body fluids at necropsy. Coroners' necropsies were grouped by gross and microscopic findings into cases of definite myocardial infarction, cases with occlusive coronary artery atheroma but no identifiable myocardial infarction, and ...

Knitter, A. E., L. Panton, J. A. Rathmacher, A. Petersen, and R. Sharp. Effects of b-hydroxy-b-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol 89: 1340–1344, 2000.—This study examined the effects of supplemental b-hydroxy-b-methylbutyrate (HMB) on muscle damage as a result of intense endurance exercise. Subjects (n 5 13) were paired according to their 2-mile run times and ...

Fractional extractions of heart muscle have revealed that about 30% of cellular creatine phosphokinase activity are located in mitochondria and about 20% are bound to myofibrils [ 1,2] . The presence of significant creatine phosphokinase activity in heart and skeletal muscle myofibrils has been demonstrated also in studies of isolated myofibrillar preparations [ 1,3,4] . This particulate enzyme...

We assessed 16 patients before and after high tibial osteotomy by electrophysiological recordings, creatine phosphokinase levels, radiographs and intracompartmental pressure monitoring. We found mild electrophysiological abnormalities pre-operatively in 12 of the 16 patients, but postoperatively these had deteriorated in 11 of the 14 patients studied. Creatine phosphokinase levels, compartment ...