SYNOPSIS The statement made in some standard textbooksthatBenedict'squalitativetestgivesa green, yellow, or orange-red precipitate with pure solutions of glucose of varying strength has been shown to be incorrect. Pure solutions ofglucose give only a bright red precipitate at all concentrations. These changes in the colour of the suspensions are observed with urinary glucose only. The differenc...

SYNOPSIS The statement made in some standard textbooksthatBenedict'squalitativetestgivesa green, yellow, or orange-red precipitate with pure solutions of glucose of varying strength has been shown to be incorrect. Pure solutions ofglucose give only a bright red precipitate at all concentrations. These changes in the colour of the suspensions are observed with urinary glucose only. The differenc...

SYNOPSIS The statement made in some standard textbooksthatBenedict'squalitativetestgivesa green, yellow, or orange-red precipitate with pure solutions of glucose of varying strength has been shown to be incorrect. Pure solutions ofglucose give only a bright red precipitate at all concentrations. These changes in the colour of the suspensions are observed with urinary glucose only. The differenc...

BACKGROUND Residual renal function (RRF) is an important predictor of outcome in peritoneal dialysis (PD) patients. Although increasing emphasis has been placed on preserving RRF, the nephrotoxicity associated with contrast medium administration in PD patients remains a controversial issue. In the present prospective study, we evaluated the evolution of RRF 2 weeks after iodinated contrast medi...

The pharmacokinetics of cefaclor and cephalexin were characterized in patients with creatinine clearances ranging from 0 to 147 ml/min. Each of 24 fasted subjects received a single 500-mg oral dose of cefaclor, and 13 of these subjects later received 500 mg of cephalexin. Serum and urine levels of the antibiotics were measured by bioassay. The serum half-lives were highly correlated with correc...

The excretion of thioethers in urine of applicators occupationally exposed to the soil fumigant 1,3-dichloropropene (DCP) was determined by the thioether assay. The mercapturic acid metabolite of E-1,3-dichloropropene, N-acetyl-S-(E-3-chloropropenyl-2-)-L-cysteine (E-DCP-MA), was the reference compound in the thioether assay. The mean recovery of E-DCP-MA was 58.5% (coefficient of variation (CV...

BACKGROUND Elevated cystatin C in blood reflects impaired glomerular filtration rate (GFR), but current cystatin C assays, based on polyclonal antibodies and immunoturbidimetric or nephelometric detection, have several limitations. We evaluated a new immunoassay based on monoclonal antibodies in samples from patients with and without chronic kidney disease (CKD). METHODS The study enrolled 17...

BACKGROUND AND OBJECTIVES This study investigated the effect of long-term storage at -70 degrees C on urinary albumin, protein, and creatinine measurements in the Family Investigation of Nephropathy and Diabetes, a multicenter study designed to identify genes for diabetic nephropathy. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Spot urine samples were collected at eight centers and shipped ...

PURPOSE To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). PATIENTS AND METHODS A total of 234 patients (mean age: 57.2±11.7 years, 75.2% were males) hospitalized with NSTEMI were included....

BACKGROUND Cystatin C-based equations are used to estimate GFR. However, three cystatin C immunoassays are on the market. Difference in cystatin C assays could have strong consequences on the accuracy and precision of cystatin C-based equations. We have performed an analytical study of these three assays and studied potential differences between assays on the precision of cystatin C-based equat...