BACKGROUND Immunodeficient children are more prone for invasive cryptococcal infections. CASE CHARACTERISTICS A 2-year-old boy with disseminated cryptococcosis was evaluated for underlying immunodeficiency without success. INTERVENTION/OUTCOME Child was managed successfully. MESSAGE Immunocompetent children with disseminated cryptococcosis can present diagnostic or therapeutic challenge i...

Cryptococcus neoformans causes severe, and often fatal, disease (cryptococcosis) in immunocompromised patients, particularly in those with HIV/AIDS. Although resistance to cryptococcosis requires intact T-cell immunity, a possible role for antibody/B cells in protection against natural disease has not been definitively established. Previous studies of the antibody response to the C. neoformans ...

Primary pulmonary cryptococcosis is difficult to diagnose because the symptoms and radiologic findings are non-specific. Further, pulmonary cryptococcal infections are extremely rare in individuals with normal immunity. This case report describes a case of primary pulmonary cryptococcosis in an immunocompetent individual who presented with left upper lobe collapse due to endobronchial occlusion.

Cryptococcus neoformans is a common cause of opportunistic infection in patients with human immunodeficiency virus (HIV) and others with cell-mediated immunodeficiency, such as patients with solid-organ-transplant-related immunosuppression, patients receiving corticosteroids or other immunosuppressive therapy, and patients with lymphoid malignancy.1,2 The central nervous system (CNS) is the mos...

Cryptococcosis is an hematogenously disseminated meningoencephalitis during which the relationship between the disease severity and the immune response remains unclear. We thus analyzed, by enzyme-linked immunosorbent assay, proinflammatory (tumor necrosis factor alpha [TNF-alpha] and interleukin-6 [IL-6]) and anti-inflammatory (IL-10) cytokine levels in plasma at the time of diagnosis in 51 AI...

OBJECTIVE We compared the epidemiology of laboratory-confirmed paediatric cryptococcal disease with adult-onset disease in the South African population. METHODS The study was an active, prospective, population-based, laboratory-based surveillance in South Africa. We compared cases of paediatric cryptococcosis (<15 years) with cases of adult-onset cryptococcosis that were reported to the surve...

Background: Cryptococcosis is an opportunistic, systemic mycotic disease caused by a yeast of Cryptococcus neoformans. These pathogens cause serious public health problems, as they can be transmitted to humans, domestic and wild animals. In cats dogs, the main site infection upper lower respiratory tract, however, extend affect other sites in organism, peritoneal manifestation rare. Thus, prese...

Cryptococcus neoformans is the most common fungal infection of the CNS. The majority of patients with cryptococcosis have preexisting immunodeficiency such as acquired immunodeficiency syndrome (AIDS). CT and/or MRI of the brain only occasionally detects abnormalities specifically related to this infection. We report a case of MR appearance of central nervous system cryptococcosis in a 33-year-...