STUDY OBJECTIVE To examine the epidemiological characteristics of boys with cryptorchidism. DESIGN Cohort survey using the Swedish personal identification code and Medical Birth Registry to link cryptorchid boys with their pregnancy and delivery data. They were compared with the total population of male births during the same period. SUBJECTS 2861 cryptorchid boys born in Sweden between 197...

Cryptorchidism or undescended testis is one of the most common anomalies encountered in paediatric urology and is estimated to affect 1 to 4 per cent of full term and upto 30 per cent of preterm male neonates. The associated problems of sub-fertility or infertility and malignant transformation have been recognized for long. Fertility is impaired after both unilateral and bilateral cryptorchidis...

Objective- Perturbation of the normal process of testicular descent results in the condition of cryptorchidism. Spermatogenesis is generally impaired in cryptorchid testes because of high intratesticular temperature. It seems that the main mechanisms underlying the process of spermatozoa demise is apoptosis by overgeneration of free radicals. So, the aim of the present study was to investigate ...

BACKGROUND The ubiquitin-proteasome system regulate p53, caspase and Bcl-2 family proteins, and is crucial for the degradation of the defective germ cells in testes. Purpose: to evaluate the concentration of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in the blood plasma of boys with cryptorchidism and if there is any correlation with patient age. METHODS Patients-50 boys aged 1-4 years (...

BACKGROUND Polybrominated diphenyl ethers (PBDEs) are widely used in Western countries. OBJECTIVES Because the prevalence of cryptorchidism appears to be increasing, we investigated whether exposure to PBDEs was associated with testicular maldescent. METHODS In a prospective Danish-Finnish study, 1997-2001, all boys were examined for cryptorchidism. We analyzed whole placentas (for 95 crypt...

Discussion on the role of DEHP in the critical period of gonadal development in pregnant rats (F0), studied the evolution of F1-F4 generation of inter-generational inheritance of cryptorchidism and the alteration of DNA methylation levels in testis. Pregnant SD rats were randomly divided into two groups: normal control group and DEHP experimental group. From pregnancy 7 d to 19 d, experimental ...