نتایج جستجو برای: csf3

تعداد نتایج: 99  

2017
Tresa George Matthew Bell Mainak Chakraborty David P Siderovski Mark A Giembycz Robert Newton

The GTPase-accelerating protein, regulator of G-protein signalling 2 (RGS2) reduces signalling from G-protein-coupled receptors (GPCRs) that signal via Gαq. In humans, RGS2 expression is up-regulated by inhaled corticosteroids (ICSs) and long-acting β2-adrenoceptor agonists (LABAs) such that synergy is produced in combination. This may contribute to the superior clinical efficacy of ICS/LABA th...

2011
Michael A. Nalls David J. Couper Toshiko Tanaka Frank J. A. van Rooij Ming-Huei Chen Albert V. Smith Daniela Toniolo Neil A. Zakai Qiong Yang Andreas Greinacher Andrew R. Wood Melissa Garcia Paolo Gasparini Yongmei Liu Thomas Lumley Aaron R. Folsom Alex P. Reiner Christian Gieger Vasiliki Lagou Janine F. Felix Henry Völzke Natalia A. Gouskova Alessandro Biffi Angela Döring Uwe Völker Sean Chong Kerri L. Wiggins Augusto Rendon Abbas Dehghan Matt Moore Kent Taylor James G. Wilson Guillaume Lettre Albert Hofman Joshua C. Bis Nicola Pirastu Caroline S. Fox Christa Meisinger Jennifer Sambrook Sampath Arepalli Matthias Nauck Holger Prokisch Jonathan Stephens Nicole L. Glazer L. Adrienne Cupples Yukinori Okada Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Tatsuhiko Tsunoda Toshihiro Tanaka Michiaki Kubo Yusuke Nakamura Kazuhiko Yamamoto Naoyuki Kamatani Michael Stumvoll Anke Tönjes Inga Prokopenko Thomas Illig Kushang V. Patel Stephen F. Garner Brigitte Kuhnel Massimo Mangino Ben A. Oostra Swee Lay Thein Josef Coresh H.-Erich Wichmann Stephan Menzel JingPing Lin Giorgio Pistis André G. Uitterlinden Tim D. Spector Alexander Teumer Gudny Eiriksdottir Vilmundur Gudnason Stefania Bandinelli Timothy M. Frayling Aravinda Chakravarti Cornelia M. van Duijn David Melzer Willem H. Ouwehand Daniel Levy Eric Boerwinkle Andrew B. Singleton Dena G. Hernandez Dan L. Longo Nicole Soranzo Jacqueline C. M. Witteman Bruce M. Psaty Luigi Ferrucci Tamara B. Harris Christopher J. O'Donnell Santhi K. Ganesh

White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied 19,509 subjects from seven cohorts in a discovery analysis, and 11,823 subjects from ten cohorts f...

Journal: :Infection and immunity 2011
Aarti Gautam Saurabh Dixit Mario T Philipp Shree R Singh Lisa A Morici Deepak Kaushal Vida A Dennis

Interleukin-10 (IL-10) modulates inflammatory responses elicited in vitro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete. How IL-10 modulates these inflammatory responses still remains elusive. We hypothesize that IL-10 inhibits effector functions of multiple genes induced by B. burgdorferi in macrophages to control concomitantly elicited inflammation. Because macrophages are ...

2016
Dianelys Gonzalez-Pena Scott E. Nixon Bruce R. Southey Marcus A. Lawson Robert H. McCusker Alvaro G. Hernandez Robert Dantzer Keith W. Kelley Sandra L. Rodriguez-Zas

Microglia in the brain and macrophages in peripheral organs are cell types responsible for immune response to challenges. Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme of the tryptophan pathway that is expressed in the brain. The higher activity of IDO1 in response to immune challenge has been implicated in behavioral disorders. The impact of IDO1 depletion on the microglia...

Journal: :Journal of immunology 2014
Hanne Schoenen Alexandra Huber Nada Sonda Stephanie Zimmermann Jonathan Jantsch Bernd Lepenies Vincenzo Bronte Roland Lang

Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, and its synthetic analog Trehalose-6,6-dibehenate (TDB) bind to the C-type lectin receptors macrophage-inducible C-type lectin (Mincle) and Mcl to activate macrophages. Genetically, the transcriptional response to TDB/TDM has been defined to require FcRγ-Syk-Card9 signaling. However, TDB/TDM-triggered kinase activation has not been ...

2016
Xuefeng Jing Takashi Sonoki Masayasu Miyajima Takahiro Sawada Nanako Terada Shigeki Takemura Kazushige Sakaguchi

UNLABELLED EphA4 belongs to the largest family of receptor tyrosine kinases (RTKs). Although EphA4 is highly expressed in the central nervous system, EphA4 has also been implicated in cancer progression. Most of the studies focus on the expression and function in tumor cells. It is unknown whether EphA4-deleted microenvironment affects tumor progression. Some of cancers in animals and humans, s...

2015
Srijata Sarkar Bey Fen Leo Claudia Carranza Shu Chen Cesar Rivas-Santiago Alexandra E. Porter Mary P. Ryan Andrew Gow Kian Fan Chung Teresa D. Tetley Junfeng (Jim) Zhang Panos G. Georgopoulos Pamela A. Ohman-Strickland Stephan Schwander David M. Ojcius

Exposure to silver nanoparticles (AgNP) used in consumer products carries potential health risks including increased susceptibility to infectious pathogens. Systematic assessments of antimicrobial macrophage immune responses in the context of AgNP exposure are important because uptake of AgNP by macrophages may lead to alterations of innate immune cell functions. In this study we examined the e...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Jingran Zhou Ruiqiong Wu Anthony A High Clive A Slaughter David Finkelstein Jerold E Rehg Vanessa Redecke Hans Häcker

Toll-like receptors (TLRs) are expressed on innate immune cells and trigger inflammation upon detection of pathogens and host tissue injury. TLR-mediated proinflammatory-signaling pathways are counteracted by partially characterized anti-inflammatory mechanisms that prevent exaggerated inflammation and host tissue damage as manifested in inflammatory diseases. We biochemically identified a comp...

Journal: :British Journal of Surgery 2021

Abstract Introduction There remains a paucity of novel therapeutics for limb salvage in patients with critical ischemia (CLI) whom revascularization procedures have failed and amputation is imminent. We shown that E-selectin+/Mesenchymal Stem Cell (MSC) injections into the ischemic tissue CLI mouse model improves function. Thus, we sought to determine mechanism action E-selectin+/MSC’s pro-angi...

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