Malignant melanoma is the eighth most common cancer in European women. Its incidence is increasing rapidly and it has been demonstrated that this is related to sun exposure. Although few cases of bilateral uveal or choroidal melanoma are described in literature, there are no cases reporting bilateral cutaneous malignant melanoma. We report a singular case of a 43-year-old woman with two primary...

The word “melanoma” was first used by Rene Laennec, inventor of the stethoscope, in his manuscript reporting a case of disseminated melanoma in 1812 [1]. Cutaneous malignant melanoma (CMM) arises from the malignant transformation of the pigment producing melanocytes, which are located and evenly distributed in the basal epidermal layer of human skin. These pigment-producing cells (melanocytes) ...

Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma, commonly seen in older adults, on sun-exposed areas. It accounts for 1-4% of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereas, other sites are less common. Regional lymph node involvement is reported in 0 to 13.7% of the cases, which is less frequent ...

Malignant melanoma currently accounts for approximately 1%, of all cancer deaths. The incidence of cutaneous melanoma is rising worldwide. The treatment of early-stage melanoma consists primarily of surgical removal of the tumour. The overall 5-years survival rate for malignant melanoma is 81%. Recently, many efforts have been made to analyse the potential significance and the possible relation...

In this chapter, cutaneous metastases from malignant melanoma will be analyzed from a clinical and a prognostic point of view. This non rare condition is often distressing for the patient, as cutaneous lesions increase progressively in number and size and are frequently worsened by ulceration, bleeding and pain. After a general introduction about the incidence of cutaneous involvement in melano...

BACKGROUND In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer. CASE REPORT A 45-year-old premenopausal woman was incidentally found to have ...

BRAF V600E mutation analysis has been an important companion diagnostic assay to evaluate prognosis of malignant melanoma and to guide target therapy with BRAF inhibitor. The aim of this study was to assess the sensitivity and specificity of Immunohistochemistry (IHC) using VE1 mutation specific antibody on screening for BRAF V600E mutation patients with cutaneous malignant melanoma. We detecte...

We herein report a rare case of gastric and regional lymph node metastasis of cutaneous malignant melanoma that underwent curative resection. The patient, a 68-year-old man, was first diagnosed as having cutaneous malignant melanoma of the right forearm in 2005. He had extensive skin excision and axillary lymph node dissection and had undergone adjuvant chemotherapy. Six years after the primary...

although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (gi) melanoma has been reported in rare cases. in this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(nf1). both cases showed no evidence of any lesions in skin and eye. malignant melanoma of gi tract...

proper differentiation between acral malignant melanoma and benign pigmented lesions like melanocytic nevi is of great value. to avoid unnecessary biopsies, dermatoscopy has been introduced as a non-invasive modality and has improved the clinical diagnostic accuracy in recent decades. we aimed to describe dermoscopic patterns of acral pigmented lesions of patients in the clinic of dermatology i...