Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that k...

Luteolin is a falvonoid compound derived from Lonicera japonica Thunb. Numerous reports have demonstrated that luteolin has anticancer effects on many kinds of tumors. This study investigated the effects of luteolin on prostate cancer (PCa), assessing the PC3 and LNCaP cells. The cell viability and apoptosis were assessed by performing Cell Counting Kit-8 assay and Annexin V-fluorescein isothio...

MA 1.1 Mon 9:30–10:00 EB 301 Composite nanoparticles and nanopatterns for ultrahigh density magnetic recording — •Dagmar Goll MA 6.1 Mon 14:00–14:30 EB 301 Genuine bulk electronic structures of strongly correlated transition metal oxides revealed by high energy photoelectron spectroscopy — •Shigemasa Suga MA 6.2 Mon 14:30–15:00 EB 301 Probing spin excitations in magnetic nanostructures and half...

Sean P. Corcoran Department of Economics University of Maryland College Park, MD 20742 Voice: (301) 405-3557 Email: [email protected] William N. Evans Department of Economics University of Maryland College Park, MD 20742 Voice: (301) 405-3486 Email: [email protected] Robert S. Schwab Department of Economics University of Maryland College Park, MD 20742 Voice: (301) 405-3478 Email: schwab@e...

A comprehensive study pertaining to the emulsion liquid membrane (ELM) extraction process to enrich dilute aqueous solutions of silver salt is presented. The study has highlighted the importance and influence of membrane composition for maximizing the extraction of Ag+ ions. The liquid membrane was made up of Cyanex-302 as an extractant and the industrial solvent mainly consists of p...

BACKGROUND The tumor necrosis factor (TNF) is believed to play an important role in the pathophysiology of osteoarthritis (OA). Evidence shows that genetic polymorphisms make substantial contributions to the etiology of OA. METHODS We investigated the genotypes TNF-α and TNF-β in 301 OA patients and 291 healthy subjects as controls. We employed a polymerase chain reaction-restriction fragment...

http://www.sciencemag.org/cgi/content/full/301/5640/1728 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/301/5640/1728/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

A phase I dose-escalation study of telomerase-specific oncolytic adenovirus, OBP-301 (Telomelysin), is now under way in the United States to assess feasibility and to characterize its pharmacokinetics in patients with advanced solid tumors. The present preclinical study investigates whether OBP-301 and a chemotherapeutic agent that is commonly used for lung cancer treatment, gemcitabine, are ab...