نتایج جستجو برای: cyclic αβ admissible mapping

تعداد نتایج: 304721  

2016
Michael T Bethune Marvin H Gee Mario Bunse Mark S Lee Eric H Gschweng Meghana S Pagadala Jing Zhou Donghui Cheng James R Heath Donald B Kohn Michael S Kuhns Wolfgang Uckert David Baltimore

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mispairing: swapping constant domains between the α and β chains of a therapeutic TCR. When paired, ...

Journal: :eLife 2015
Elisabeth A Geyer Alexander Burns Beth A Lalonde Xuecheng Ye Felipe-Andres Piedra Tim C Huffaker Luke M Rice

Microtubule dynamic instability depends on the GTPase activity of the polymerizing αβ-tubulin subunits, which cycle through at least three distinct conformations as they move into and out of microtubules. How this conformational cycle contributes to microtubule growing, shrinking, and switching remains unknown. Here, we report that a buried mutation in αβ-tubulin yields microtubules with dramat...

2014
Daniel G. Pellicci Adam P. Uldrich Jérôme Le Nours Fiona Ross Eric Chabrol Sidonia B.G. Eckle Renate de Boer Ricky T. Lim Kirsty McPherson Gurdyal Besra Amy R. Howell Lorenzo Moretta James McCluskey Mirjam H.M. Heemskerk Stephanie Gras Jamie Rossjohn Dale I. Godfrey

αβ and γδ T cells are disparate T cell lineages that can respond to distinct antigens (Ags) via the use of the αβ and γδ T cell Ag receptors (TCRs), respectively. Here we characterize a population of human T cells, which we term δ/αβ T cells, expressing TCRs comprised of a TCR-δ variable gene (Vδ1) fused to joining α and constant α domains, paired with an array of TCR-β chains. We demonstrate t...

Journal: :Remote Sensing 2018
Sungho Kim Woo-Jin Song So-Hyun Kim

This paper presents a novel double weight-based synthetic aperture radar (SAR) and infrared (IR) sensor fusion method (DW-SIF) for automatic ground target recognition (ATR). IR-based ATR can provide accurate recognition because of its high image resolution but it is affected by the weather conditions. On the other hand, SAR-based ATR shows a low recognition rate due to the noisy low resolution ...

Journal: :journal of sciences islamic republic of iran 0

in this paper, we consider admissible estimation of the parameter ?r in the gamma distribution with truncated parameter space under entropy loss function. we obtain the classes of admissible estimators. the result can be applied to estimation of parameters in the normal, lognormal, pareto, generalized gamma, generalized laplace and other distributions.

Journal: :Journal of function spaces 2021

This paper is aimed at presenting some coincidence point results using admissible mapping in the framework of partial b -metric spaces. Observed article cover a number existing works on topic “investigation nonunique fixed points.” We express an example to indicate validity observed outcomes.

2014
M. R. Yadav A. K. Sharma B. S. Thakur

The purpose of this paper is to present a best proximity point theorems through rational expression for a combination of contraction condition, Kannan and Chatterjea nonlinear cyclic contraction in what we call MT-K and MT-C rational cyclic contraction. Some best proximity point theorems for a mapping satisfy these conditions have been established in metric spaces. We also give some examples to...

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