CD38 is a multifunctional enzyme for the synthesis of Ca(2+) second messengers. Glucagon promotes hepatic glucose production through Ca(2+) signaling in the fasting condition. In this study, we investigated the role of CD38 in the glucagon signaling of hepatocytes. Here, we show that glucagon induces cyclic ADP-ribose (cADPR) production and sustained Ca(2+) increases via CD38 in hepatocytes. 8-...

Calorie restriction (CR) and fasting affect lifespan, disease susceptibility response to acute injury across multiple animal models, including ischaemic injuries such as myocardial infarction or kidney hypoxia. The cargo function of circulating extracellular vesicles (EV) respond changes in host physiology, exercise, injury, other interventions. Thus, we hypothesised that EVs induced following ...

muslims all over the world fast in the holy month of ramadan. fasting means abstinence from drinking any liquids, eating, smoking and taking anything parenterally.  it is intermittent in nature from the start of dawn to end at dusk. fasting has various physiological effects on different biological parameters of the human body. previous studies that look at effect of ramadan fasting on blood pre...

in a large scale cyclic storage system ,as the number of rule parameters and/or number of operating period increase, general purpose gradient-based nlp solvers and/or genetic algorithms may loose their merits in finding optimally feasible solution to the problem. in these cases hybrid ga which decomposes the main problem into two manageable sub-problems with an iterative scheme between ga and l...

BACKGROUND 5-hydroxytryptamine (5-HT) is released into the intestinal lumen during the fasting state. However, the relationship between the intraduodenal 5-HT and the interdigestive cyclic motor activity in conscious dogs is unclear. AIM To correlate intraduodenal 5-HT concentrations with the interdigestive gastroduodenal migrating motor complex (MMC). METHODS 6 dogs were implanted with 2 f...

Expression of hepatic lipase (HL) in the liver is reduced during prolonged fasting. This effect is mainly mediated via catecholamines, which signal through elevation of Ca(i)(2+) as well as cAMP. We have studied the effect of cAMP on HL expression in cell culture. Overnight incubation of HepG2 cells with 10-300microM 8-bromo-cyclic AMP resulted in a dose-dependent, up to 50% reduction in secret...

ramadan is a holy month for muslims and fasting in this month is the rule for any healthy matured person. nutritional and behavioral changes occurred during ramadan fasting may lead to several physiological change, such as blood pressure (2). studies evaluated the effects of ramadan fasting on blood pressure in hypertensive patients, are scarce and reported inadequate results. in this paper a s...