The mechanism of action of antimicrobial peptides is, to our knowledge, still poorly understood. To probe the biophysical characteristics that confer activity, we present here a molecular-dynamics and biophysical study of a cyclic antimicrobial peptide and its inactive linear analog. In the simulations, the cyclic peptide caused large perturbations in the bilayer and cooperatively opened a diso...

Cyclic nucleotide-sensitive ion channels, known as HCN and CNG channels, are crucial in neuronal excitability and signal transduction of sensory cells. HCN and CNG channels are activated by binding of cyclic nucleotides to their intracellular cyclic nucleotide-binding domain (CNBD). However, the mechanism by which the binding of cyclic nucleotides opens these channels is not well understood. He...

Tridiagonal systems play a fundamental role in matrix computation. In particular, in recent years parallel algorithms for the solution of tridiagonal systems have been developed. Among these, the cyclic reduction algorithm is particularly interesting. Here the stability of the cyclic reduction method is studied under the assumption of diagonal dominance. A backward error analysis is made, yield...

As computer architectures move towards multicore we must build a theoretical understanding of parallelism in machine learning. In this paper we focus on parallel inference in graphical models. We demonstrate that the natural, fully synchronous parallelization of belief propagation is highly inefficient. By bounding the achievable parallel performance in chain graphical models we develop a theor...

An eecient template for the implementation on distributed-memory multiprocessors of iterated parallel loops, i.e. parallel loops nested in a sequential loop, is presented. The template is explicitly designed to smooth unbalanced processor workloads deriving from loops whose iterations are characterized by highly varying execution times. Experiments conducted shows performance gains w.r.t. HPF-l...

Error detection is important whenever there is a non-zero chance of data getting corrupted. A Cyclic Redundancy Check (CRC) is the remainder, or residue, of binary division of a potentially long message, by a CRC polynomial. This technique is ubiquitously employed in communication and storage applications due to its effectiveness at detecting errors and malicious tampering. The hardware impleme...

The paper deals with the study of Z-symmetric manifolds (ZS)n admitting certain cases Schouten tensor (specifically: Ricci-recurrent, cyclic parallel, Codazzi type and covariantly constant), investigate some geometric physical properties manifold. Moreover, we also (ZS)4 spacetimes tensor. Finally, construct an example to verify our result.

Abstract: In chloride salt solutions, titanium alloys exhibit reasonably high pitting potentials as high as +10 V (vs. Ag/AgCl) at room temperatures. On the other hand, anodic pitting potentials are significantly lower in bromide solutions. In this study, pitting corrosion of commercially pure titanium in aqueous NaBr solution of 0.1 M concentration at room temperature was studied and the e...

Debugging MIMD programs is often a delicate job. As a matter of fact, they can have diierent behaviors in successive executions. So, cyclic debugging is not applicable. To make it available for parallel programmers , we propose execution replay (full and partial) for our multi-threaded execution model, the Communicating Active Components (CAC). CAC/s have been deened to implement Parallel Objec...